Flecainide

300 interactions 706 cited references
Also sold as: Tambocor®
About Flecainide

Flecainide is an antiarrhythmic medication used to prevent certain life-threatening irregular heartbeats. Read the full Flecainide drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Flecainide Asenapine Saphris Increased flecainide exposure, an increased asenapine exposure, an increased risk of QT interval prolongation and an increased ris... Details Flecainide Astemizole An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Flecainide Atazanavir Reyataz Increased antiarrhythmic exposure and an increased risk of QT interval prolongation Details Flecainide Azimilide An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Flecainide Bendroflumethiazide Increased risk of electrolyte imbalance and subsequent cardiotoxicity Details Flecainide Berotralstat Orladeyo Increased CYP2D6 substrate exposure Details Flecainide Boceprevir Increased flecainide plasma concentrations Details Flecainide Bretylium An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Flecainide Bupropion Aplenzin Increased exposure of CYP2D6 substrates Details Flecainide Celecoxib Celebrex Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse effects Details Flecainide Ceritinib Zykadia An increased risk of QT interval prolongation Details Flecainide Chloral Hydrate An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Flecainide Chlorothiazide Diuril Increased risk of electrolyte imbalance and subsequent cardiotoxicity Details Flecainide Chlorpromazine An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Flecainide Chlorthalidone Hemiclor Increased risk of electrolyte imbalance and subsequent cardiotoxicity Details Flecainide Ciprofloxacin An increased risk of QT interval prolongation and torsade de pointes Details Flecainide Citalopram Celexa An increased risk of QT interval prolongation Details Flecainide Clarithromycin Biaxin Increased risk of QT interval prolongation Details Flecainide Clofazimine An increased risk of QT interval prolongation Details Flecainide Clomipramine Anafranil Increased clomiPRAMINE exposure and an increased risk of QT interval prolongation Details Flecainide Clothiapine Increased risk of cardiac arrhythmias Details Flecainide Clozapine Clozaril Increased risk of QT interval prolongation Details Flecainide Crizotinib Xalkori An increased risk of QT interval prolongation Details Flecainide Cyclobenzaprine Amrix An increased risk of QT interval prolongation Details Flecainide Dabrafenib Tafinlar An increased risk of QT interval prolongation Details Flecainide Darifenacin Enablex Increased flecainide exposure with an increased risk of cardiac arrhythmias Details Flecainide Dasabuvir Increased plasma concentration of antiarrhythmic agent Details Flecainide Degarelix Firmagon Increased risk of QT interval prolongation Details Flecainide Delamanid Increased risk of QT interval prolongation Details Flecainide Delavirdine Rescriptor® Increased flecainide levels Details Flecainide Desflurane Suprane An increased risk of QT interval prolongation Details Flecainide Desipramine Norpramin An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Flecainide Desvenlafaxine Pristiq Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse events Details Flecainide Dexmedetomidine Dexased Increased risk of cardiac arrhythmias Details Flecainide Dextroamphetamine Dexedrine Increased dextroamphetamine or lisdexamfetamine (prodrug of dextroamphetamine) exposure and an increased risk of serotonin syndrom... Details Flecainide Dibenzepin An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Flecainide Dihydrocodeine Increased dihydrocodeine exposure and reduced exposure of active metabolite Details Flecainide Domperidone Increased risk of QT interval prolongation Details Flecainide Donepezil Adlarity Increased risk of QT-interval prolongation and torsade de pointes Details Flecainide Dordaviprone An increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.