Flecainide

300 interactions 706 cited references
Also sold as: Tambocor®
About Flecainide

Flecainide is an antiarrhythmic medication used to prevent certain life-threatening irregular heartbeats. Read the full Flecainide drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Flecainide Doxepin Prudoxin An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Flecainide Droperidol An increased risk of QT interval prolongation Details Flecainide Duloxetine Increased class IC antiarrhythmic serum concentrations and an increased risk of cardiotoxicity (QT prolongation, torsades de point... Details Flecainide Efavirenz An increased risk of QT interval prolongation Details Flecainide Enflurane An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Flecainide Epinephrine An increased risk of cardiac arrhythmias Details Flecainide Erythromycin Erythrocin Stearate Increased risk of QT interval prolongation Details Flecainide Escitalopram Lexapro An increased risk of QT interval prolongation and increased CYP2D6 substrate exposure Details Flecainide Etrasimod Velsipity Increased risk of transient reduction in heart rate, AV conduction, QT interval prolongation and an increased risk of torsade de p... Details Flecainide Etravirine Intelence Decreased flecainide plasma concentrations Details Flecainide Fedratinib Inrebic Increased CYP2D6 substrate exposure Details Flecainide Fexinidazole An increased risk of QT interval prolongation Details Flecainide Fingolimod Gilenya Increased risk of QT interval prolongation Details Flecainide Fluconazole Diflucan An increased risk of QT interval prolongation Details Flecainide Fluoxetine RECONCILE Increased flecainide exposure and an increased risk of QT interval prolongation Details Flecainide Formoterol Perforomist Increased risk of QT interval prolongation and an increased risk of cardiovascular adverse effects Details Flecainide Foscarnet Foscavir An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Flecainide Fosfomycin Contepo An increased risk of QT interval prolongation Details Flecainide Fosphenytoin Cerebyx An increased risk of QT interval prolongation Details Flecainide Fostemsavir Rukobia Increased risk of torsade de pointes Details Flecainide Gatifloxacin Zymaxid An increased risk of QT interval prolongation Details Flecainide Gemifloxacin Factive An increased risk of QT interval prolongation Details Flecainide Gepirone Exxua An increased risk of QT interval prolongation and cardiac arrhythmias Details Flecainide Gepotidacin Blujepa An increased risk of QT interval prolongation Details Flecainide Givinostat Duvyzat Increased risk of QT interval prolongation and torsade de pointes Details Flecainide Glasdegib Daurismo Increased risk of QT interval prolongation Details Flecainide Goserelin Increased risk of QT interval prolongation Details Flecainide Granisetron An increased risk of QT interval prolongation Details Flecainide Halofantrine An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Flecainide Haloperidol Increased haloperidol exposure, an increased risk of haloperidol-related adverse events and an increased risk of QT interval prolo... Details Flecainide Halothane An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Flecainide Histrelin Supprelin Increased risk of QT interval prolongation Details Flecainide Hydrochlorothiazide Inzirqo Increased risk of electrolyte imbalance and subsequent cardiotoxicity Details Flecainide Hydroflumethiazide Increased risk of electrolyte imbalance and subsequent cardiotoxicity Details Flecainide Hydroquinidine An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Flecainide Hydroxychloroquine Plaquenil Increased risk of QT interval prolongation Details Flecainide Hydroxyzine An increased risk of QT interval prolongation Details Flecainide Ibutilide Corvert An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Flecainide Iloperidone Fanapt An increased risk of QT interval prolongation Details Flecainide Imatinib Gleevec Increased CYP2D6 substrate exposure with NTI exposure and an increased risk of CYP2D6 substrates with NTI-related adverse reaction... Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.