Flecainide

300 interactions 706 cited references

Also sold as: Tambocor®

About Flecainide

Flecainide is an antiarrhythmic medication used to prevent certain life-threatening irregular heartbeats. Read the full Flecainide drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Pimozide Ritonavir Mesoridazine Piperaquine Nirmatrelvir Mavorixafor

18 Contraindicated 270 Major 11 Moderate 1 Minor

All (300) Contraindicated (18) Major (270) Moderate (11) Minor (1)

Major

Flecainide Olanzapine An increased risk of QT interval prolongation Details Flecainide Olodaterol Striverdi An increased risk of QT interval prolongation and an increased risk of ventricular arrhythmias Details Flecainide Ombitasvir Increased concentration of the antiarrhythmic agent Details Flecainide Ondansetron An increased risk of QT interval prolongation Details Flecainide Osilodrostat Isturisa Increased risk of QT interval prolongation Details Flecainide Osimertinib Tagrisso Increased risk of QT interval prolongation Details Flecainide Oxaliplatin Increased risk of QT-interval prolongation Details Flecainide Ozanimod Additive effects on heart rate Details Flecainide Pacritinib Vonjo® An increased risk of QT interval prolongation Details Flecainide Paliperidone Erzofri An increased risk of QT interval prolongation and torsade de pointes Details Flecainide Panobinostat Farydak Increased risk of QT interval prolongation Details Flecainide Paritaprevir Increased exposure of antiarrhythmic drug Details Flecainide Paroxetine Paxil Increased risk of QT interval prolongation, increased flecainide exposure and an increased risk of flecainide toxicity (cardiac ar... Details Flecainide Pasireotide Signifor Increased risk of QT prolongation Details Flecainide Pazopanib Votrient Increased flecainide exposure and increased risk of QT-interval prolongation Details Flecainide Peginterferon Alfa-2B Increased exposure CYP2D6 substrate and increased risk for toxicities Details Flecainide Pentamidine NebuPent An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Flecainide Phenobarbital Fidoquel An increased risk of QT interval prolongation Details Flecainide Pimavanserin Nuplazid An increased risk of QT interval prolongation Details Flecainide Pirmenol An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Flecainide Pitolisant Wakix Increased risk of QT interval prolongation Details Flecainide Polythiazide Increased risk of electrolyte imbalance and subsequent cardiotoxicity Details Flecainide Ponesimod Ponvory An increased risk of QT interval prolongation Details Flecainide Posaconazole Noxafil An increased risk of QT interval prolongation Details Flecainide Prajmaline An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Flecainide Prilocaine An increased risk of cardiotoxicity Details Flecainide Primidone Mysoline An increased risk of QT interval prolongation Details Flecainide Probucol An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Flecainide Procainamide Procan® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Flecainide Prochlorperazine An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Flecainide Promethazine Phenadoz An increased risk of QT interval prolongation Details Flecainide Propafenone Rythmol An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Flecainide Protriptyline An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Flecainide Quetiapine Seroquel An increased risk of QT interval prolongation Details Flecainide Quinidine Cardioquin® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Flecainide Quizartinib Vanflyta An increased risk of QT interval prolongation Details Flecainide Ranolazine Aspruzyo Increased CYP2D6 substrates exposure and an increased risk of QT interval prolongation Details Flecainide Revumenib Revuforj An increased risk of QT interval prolongation Details Flecainide Ribociclib Kisqali An increased risk of QT interval prolongation Details Flecainide Rilpivirine Edurant An increased risk of QT interval prolongation and torsade de pointes Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.