Flecainide

300 interactions 706 cited references

Also sold as: Tambocor®

About Flecainide

Flecainide is an antiarrhythmic medication used to prevent certain life-threatening irregular heartbeats. Read the full Flecainide drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Pimozide Ritonavir Mesoridazine Piperaquine Nirmatrelvir Mavorixafor

18 Contraindicated 270 Major 11 Moderate 1 Minor

All (300) Contraindicated (18) Major (270) Moderate (11) Minor (1)

Major

Flecainide Vepdegestrant Veppanu An increased risk of QT interval prolongation and an increased risk of torsade de pointes, polymorphic ventricular tachycardia, ot... Details Flecainide Vilanterol An increased risk of QT interval prolongation Details Flecainide Vinflunine Increased risk of QT-interval prolongation Details Flecainide Voclosporin Lupkynis An increased risk of QT interval prolongation Details Flecainide Voriconazole Vfend An increased risk of QT interval prolongation Details Flecainide Ziftomenib Komzifti An increased risk of QT interval prolongation and torsade de pointes Details Flecainide Zolmitriptan Zomig An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Flecainide Zotepine An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Flecainide Zuclopenthixol An increased risk of QT interval prolongation Details Flecainide Foscarnet Injection Foscavir An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Flecainide Gatifloxacin Ophthalmic Zymar® An increased risk of QT interval prolongation Details Flecainide Goserelin Implant Zoladex Increased risk of QT interval prolongation Details Flecainide Granisetron Transdermal Patch Sancuso An increased risk of QT interval prolongation Details Flecainide Granisetron Injection Granisol An increased risk of QT interval prolongation Details Flecainide Histrelin Implant Supprelin Increased risk of QT interval prolongation Details Flecainide Inotuzumab Ozogamicin Injection Besponsa Increased risk of QT interval prolongation Details Flecainide Ketoconazole Topical Extina® Foam Increased risk of QT interval prolongation Details Flecainide Lacosamide Injection Motpoly An increased risk of AV block, bradycardia, and ventricular tachyarrhythmia Details Flecainide Levofloxacin Injection Levaquin Increased risk of QT interval prolongation Details Flecainide Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Flecainide Metronidazole Injection Flagyl An increased risk of QT interval prolongation Details Flecainide Metronidazole Topical MetroCream® An increased risk of QT interval prolongation Details Flecainide Metronidazole Vaginal MetroGel® Vaginal An increased risk of QT interval prolongation Details Flecainide Moxifloxacin Injection Avelox Increased risk of QT interval prolongation Details Flecainide Moxifloxacin Ophthalmic Moxeza® Increased risk of QT interval prolongation Details Flecainide Octreotide Injection Bynfezia An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Flecainide Ofloxacin Ophthalmic Ocuflox An increased risk of QT interval prolongation Details Flecainide Ofloxacin Otic Floxin® Otic An increased risk of QT interval prolongation Details Flecainide Olodaterol Oral Inhalation Striverdi An increased risk of QT interval prolongation and an increased risk of ventricular arrhythmias Details Flecainide Oxaliplatin Injection Eloxatin® Increased risk of QT-interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.