Fondaparinux

204 interactions 288 cited references

Also sold as: Arixtra

Read the full Fondaparinux drug information page

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Defibrotide Defibrotide Injection Sulindac St John's Wort Streptokinase Omadacycline Injection

2 Contraindicated 157 Major 43 Moderate 2 Minor

All (204) Contraindicated (2) Major (157) Moderate (43) Minor (2)

Major

Fondaparinux Sertraline An increased risk of bleeding Details Fondaparinux Apixaban Eliquis An increased risk of bleeding and can cause serious, potentially fatal bleeding Details Fondaparinux Aspirin Acuprin® Increased risk of bleeding Details Fondaparinux Aspirin Rectal Aspirin Increased risk of bleeding Details Fondaparinux Betrixaban Bevyxxa® Increased risk of bleeding Details Fondaparinux Anagrelide Agrylin Increased risk of bleeding Details Fondaparinux Bromfenac Ophthalmic Bromday® An increased risk of bleeding Details Fondaparinux Caplacizumab-Yhdp Injection Cablivi An increased risk of bleeding Details Fondaparinux Clopidogrel Plavix Increased risk of bleeding Details Fondaparinux Dabigatran Pradaxa® An increased risk of bleeding Details Fondaparinux Dabigatran Etexilate An increased risk of bleeding Details Fondaparinux Dalteparin Injection Fragmin Increased risk of bleeding Details Fondaparinux Diclofenac Ophthalmic Voltaren® Eye Drops An increased risk of bleeding Details Fondaparinux Diclofenac Topical (Actinic Keratosis) Pennsaid An increased risk of bleeding Details Fondaparinux Diclofenac Topical (Arthritis Pain) Pennsaid® An increased risk of bleeding Details Fondaparinux Diclofenac Transdermal Patch Flector An increased risk of bleeding Details Fondaparinux Dipyridamole Permole® Increased risk of bleeding Details Fondaparinux Doxycycline Injection Acticlate An increased risk of bleeding Details Fondaparinux Edoxaban Savaysa Increased risk of bleeding Details Fondaparinux Enoxaparin Lovenox Increased risk of bleeding Details Fondaparinux Enoxaparin Injection Lovenox Increased risk of bleeding Details Fondaparinux Epoprostenol Flolan Increased risk of bleeding Details Fondaparinux Etodolac Lodine An increased risk of bleeding Details Fondaparinux Fenoprofen Fenopron An increased risk of bleeding Details Fondaparinux Flurbiprofen Ansaid An increased risk of bleeding Details Fondaparinux Flurbiprofen Ophthalmic Ocufen An increased risk of bleeding Details Fondaparinux Abciximab An increased risk of bleeding Details Fondaparinux Aceclofenac An increased risk of bleeding Details Fondaparinux Acemetacin An increased risk of bleeding Details Fondaparinux Alipogene Tiparvovec An increased risk of bleeding Details Fondaparinux Alteplase, Recombinant Activase An increased risk of bleeding Details Fondaparinux Amtolmetin Guacil An increased risk of bleeding Details Fondaparinux Anistreplase An increased risk of bleeding Details Fondaparinux Argatroban Increased risk of bleeding Details Fondaparinux Bemiparin Increased risk of bleeding Details Fondaparinux Bivalirudin Angiomax Increased risk of bleeding Details Fondaparinux Bromfenac Bromsite An increased risk of bleeding Details Fondaparinux Bufexamac An increased risk of bleeding Details Fondaparinux Cangrelor Kengreal Increased risk of bleeding Details Fondaparinux Caplacizumab-Yhdp An increased risk of bleeding Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.