Fondaparinux

204 interactions 288 cited references

Also sold as: Arixtra

Read the full Fondaparinux drug information page

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Defibrotide Defibrotide Injection Sulindac St John's Wort Streptokinase Omadacycline Injection

2 Contraindicated 157 Major 43 Moderate 2 Minor

All (204) Contraindicated (2) Major (157) Moderate (43) Minor (2)

Major

Fondaparinux Rivaroxaban Xarelto An increased risk of bleeding Details Fondaparinux Rofecoxib An increased risk of bleeding Details Fondaparinux Sarecycline Seysara Increased risk of bleeding Details Fondaparinux Selexipag Uptravi Increased risk of bleeding Details Fondaparinux St John's Wort Reduced anticoagulants exposure and reduced efficacy of anticoagulants Details Fondaparinux Streptokinase An increased risk of bleeding Details Fondaparinux Sulfinpyrazone Increased risk of bleeding Details Fondaparinux Sulindac Clinoril® An increased risk of bleeding Details Fondaparinux Tan-Shen Increased risk of bleeding Details Fondaparinux Tazobactam An increased risk of bleeding Details Fondaparinux Tenecteplase An increased risk of bleeding Details Fondaparinux Tenoxicam An increased risk of bleeding Details Fondaparinux Tiaprofenic Acid An increased risk of bleeding Details Fondaparinux Ticagrelor Brilinta Increased risk of bleeding Details Fondaparinux Ticlopidine Ticlid® Increased risk of bleeding Details Fondaparinux Tirofiban Increased risk of bleeding Details Fondaparinux Tolfenamic Acid An increased risk of bleeding Details Fondaparinux Tolmetin Tolectin 600 An increased risk of bleeding Details Fondaparinux Trazodone Raldesy Increased risk of bleeding Details Fondaparinux Treprostinil Orenitram Increased risk of bleeding Details Fondaparinux Turmeric An increased risk of bleeding Details Fondaparinux Urokinase An increased risk of bleeding Details Fondaparinux Valdecoxib Increased risk of bleeding Details Fondaparinux Venlafaxine An increased risk of bleeding Details Fondaparinux Vilazodone Viibryd An increased risk of bleeding Details Fondaparinux Vorapaxar Zontivity Increased risk of bleeding, including intracranial hemorrhage and fatal bleeding Details Fondaparinux Vortioxetine Trintellix An increased risk of bleeding Details Fondaparinux Warfarin Coumadin An increased risk of bleeding Details Fondaparinux Zanubrutinib Brukinsa An increased risk of bleeding Details Fondaparinux Heparin Injection Lipo-Hepin® Increased risk of bleeding Details Fondaparinux Ketorolac Injection Acular An increased risk of bleeding Details Fondaparinux Ketorolac Nasal Spray Sprix An increased risk of bleeding Details Fondaparinux Ketorolac Ophthalmic Acular An increased risk of bleeding Details Fondaparinux Lecanemab-Irmb Injection Leqembi An increased risk of amyloid related imaging abnormalities (ARIA), or intracerebral hemorrhage Details Fondaparinux Meloxicam Injection Alloxate An increased risk of bleeding Details Fondaparinux Minocycline Topical Amzeeq An increased risk of bleeding Details Fondaparinux Omadacycline Injection Nuzyra Increased risk of bleeding Details

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