Gemfibrozil and Atogepant: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Atogepant
Gemfibrozil
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased atogepant exposure
Interaction Deep Dive
Coadministration of atogepant (OATP substrate) with an OATP inhibitor may significantly increase atogepant exposure. In a pharmacokinetic study, coadministration of atogepant with a single dose of rifAMPin (OATP inhibitor) increased atogepant AUC by 2.85-fold and Cmax by 2.23-fold. For episodic migraine, the recommended dosage of atogepant with concomitant use of OATP inhibitors is 10 mg or 30 mg once daily. For chronic migraine, the recommended dosage of atogepant with concomitant use of OATP inhibitors is 30 mg once daily1.
Why it happens (mechanism)
Inhibition of OATP-mediated transport of atogepant
Literature reports
1 report — tap to read
a) In a pharmacokinetic study, coadministration of atogepant with a single dose of rifAMPin (OATP inhibitor) increased atogepant AUC by 2.85-fold and Cmax by 2.23-fold in healthy subjects 1.
Common questions
Can I take Gemfibrozil and Atogepant together?
Increased atogepant exposure Always confirm with your pharmacist or prescriber before making any change.
How serious is the Gemfibrozil and Atogepant interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
Questions for your pharmacist
- Does my dose of Gemfibrozil or Atogepant need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: QULIPTA(R) oral tablets, atogepant oral tablets. AbbVie Inc (per FDA), North Chicago, IL, 2025. DailyMed
Keep reading about Atogepant
Keep reading about Gemfibrozil
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
Check another combination
Our instant two-drug interaction checker is almost here.
Still have questions about this combination?
Every question gets a real answer from a licensed pharmacist — free, and usually within a day.
Ask the pharmacist