Drug Interaction Report

Glyburide and Fluvastatin: Interaction Details

A pharmacist-reviewed analysis of the Glyburide and Fluvastatin interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Glyburide

DiaBeta® Glynase Glynase® Micronase®
+

Fluvastatin

Lescol Lescol® Lescol® XL
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
Updated Aug 8, 2026
Editorial policy · Data sources
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Interaction severity
Moderate
Can be significant — usually manageable with monitoring.
How we grade severity & evidence

Severity levels

  • Contraindicated: These should generally not be used together.
  • Major: Potentially serious — often needs a change or close monitoring.
  • Moderate: Can be significant — usually manageable with monitoring.
  • Minor: Usually limited clinical impact.

Evidence grades

  • Established: Well documented — supported by controlled studies or strong clinical data.
  • Probable: Good supporting evidence, though not definitively proven.
  • Suspected: Some evidence suggests this interaction, but it is not well established.
  • Possible: Limited or conflicting evidence; the interaction may occur.
  • Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Of 79 documented Glyburide interactions, 37 are rated moderate — including this one.
Onset
delayed
Evidence
probable
Severity
Moderate

What happens

Increased glyBURIDE exposure

Interaction Deep Dive

Concomitant administration of fluvastatin and glyBURIDE may lead to increased glyBURIDE exposure. A pharmacokinetic study found the mean glyBURIDE AUC and Cmax to be 70% and 50% greater, respectively, when coadministered with fluvastatin. Blood glucose monitoring is recommended in patients receiving concurrent therapy21.

Why it happens (mechanism)

Unknown

Literature reports

1 report — tap to read

a) In a pharmacokinetic study, coadministration of fluvastatin 40 mg twice daily for 21 days with glyBURIDE 5 mg to 20 mg daily for 22 days was associated with mean glyBURIDE AUC and Cmax levels 70% and 50% greater, respectively, compared with glyBURIDE monotherapy 21.

Common questions

Can I take Glyburide and Fluvastatin together?

Increased glyBURIDE exposure Always confirm with your pharmacist or prescriber before making any change.

How serious is the Glyburide and Fluvastatin interaction?

It is rated moderate. Can be significant — usually manageable with monitoring.

How quickly could this interaction happen?

The documented onset is "delayed". Effects tend to build up gradually over days to weeks.

How strong is the evidence for this interaction?

The evidence is graded "probable". Good supporting evidence, though not definitively proven.

Questions for your pharmacist

  • Does my dose of Glyburide or Fluvastatin need adjusting while I take them together?
  • What symptoms should prompt me to call you or my prescriber right away?
  • Does the timing of my doses matter for this combination?
  • Is there anything you'd monitor while I'm on both?

References (2)

  1. Product Information: Lescol(R) XL oral extended release tablets, fluvastatin sodium oral extended release tablets. Sandoz, Inc.(per FDA), Princeton, NJ, 2023. DailyMed
  2. Product Information: LESCOL(R) oral capsules, fluvastatin sodium oral capsules. Novartis Pharmaceuticals Corporation (Per FDA), East Hanover, NJ, 2012. DailyMed
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Glyburide

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All Glyburide interactions (79) Glyburide drug information
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Fluvastatin

Keep reading about Fluvastatin

All Fluvastatin interactions (76) Fluvastatin drug information
Also serious with: Posaconazole Meloxicam Injection Leniolisib Danazol
Beyond drug–drug

These medications also interact with supplements

Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:

Glyburide + Activated Charcoal Apple Beer Grapefruit Siberian Cocklebur Sweet Orange Wine Acai + 323 more
Fluvastatin + Activated Charcoal Apple Beer Grapefruit Siberian Cocklebur Sweet Orange Wine Adrafinil + 120 more

major · moderate · minor — check everything you take with our drug–supplement interaction checker.

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This information is for education, not a substitute for professional medical advice. Do not start, stop, or change any medication without talking to your pharmacist or prescriber.