Granisetron

66 interactions 5 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Moxifloxacin Ophthalmic Lithium Carbonate Disopyramide Dolasetron Injection Deutetrabenazine Palonosetron Injection
66 Major
All (66) Major (66)

Major

Granisetron Ketoconazole Topical Extina® Foam Increased risk of QT interval prolongation Details Granisetron Lefamulin Xenleta Increased risk of QT interval prolongation Details Granisetron Lenvatinib Lenvima Increased risk of QT-interval prolongation Details Granisetron Levofloxacin Levaquin Increased risk of QT interval prolongation Details Granisetron Levofloxacin Injection Levaquin Increased risk of QT interval prolongation Details Granisetron Linezolid Injection Zyvox Increased risk of serotonin syndrome Details Granisetron Lithium Carbonate Lithobid Increased risk of serotonin syndrome Details Granisetron Loperamide Diamode An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Granisetron Mefloquine Lariam® An increased risk of QT interval prolongation Details Granisetron Metronidazole Flagyl An increased risk of QT interval prolongation Details Granisetron Metronidazole Injection Flagyl An increased risk of QT interval prolongation Details Granisetron Metronidazole Topical MetroCream® An increased risk of QT interval prolongation Details Granisetron Metronidazole Vaginal MetroGel® Vaginal An increased risk of QT interval prolongation Details Granisetron Morphine Injection Astramorph® PF Increased risk of serotonin syndrome Details Granisetron Moxifloxacin Avelox Increased risk of QT interval prolongation Details Granisetron Moxifloxacin Injection Avelox Increased risk of QT interval prolongation Details Granisetron Moxifloxacin Ophthalmic Moxeza® Increased risk of QT interval prolongation Details Granisetron Nalbuphine Injection Nubain® Increased risk of serotonin syndrome Details Granisetron Octreotide Bynfezia An increased risk of QT interval prolongation Details Granisetron Octreotide Injection Bynfezia An increased risk of QT interval prolongation Details Granisetron Ofloxacin Floxin® An increased risk of QT interval prolongation Details Granisetron Ofloxacin Ophthalmic Ocuflox An increased risk of QT interval prolongation Details Granisetron Ofloxacin Otic Floxin® Otic An increased risk of QT interval prolongation Details Granisetron Olodaterol Oral Inhalation Striverdi An increased risk of QT interval prolongation and an increased risk of ventricular arrhythmias Details Granisetron Oxaliplatin Injection Eloxatin® Increased risk of QT-interval prolongation Details Granisetron Palonosetron Injection Aloxi® Increased risk of serotonin syndrome Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.