Halofantrine

59 interactions 4 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketoconazole Topical Oxaliplatin Injection Disopyramide Dolasetron Injection Deutetrabenazine Fostemsavir
1 Contraindicated 57 Major 1 Moderate
All (59) Contraindicated (1) Major (57) Moderate (1)

Major

Halofantrine Amitriptyline Elavil Explained An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Halofantrine Sertraline Explained An increased risk of QT interval prolongation Details Halofantrine Buprenorphine Belbuca Explained An increased risk of QT interval prolongation Details Halofantrine Relugolix Orgovyx Explained Increased risk of QT interval prolongation Details Halofantrine Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Halofantrine Arsenic Trioxide Trisenox An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Halofantrine Aripiprazole Injection Abilify An increased risk of QT interval prolongation Details Halofantrine Arsenic Trioxide Injection Trisenox An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Halofantrine Asenapine Transdermal Patch Secuado Increased risk of QT interval prolongation Details Halofantrine Azithromycin AzaSite An increased risk of QT interval prolongation Details Halofantrine Alfuzosin UroXatral An increased risk of QT interval prolongation Details Halofantrine Anagrelide Agrylin Increased risk of QT interval prolongation Details Halofantrine Bedaquiline Sirturo Increased risk of QT interval prolongation Details Halofantrine Chloroquine Aralen® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Halofantrine Dasatinib Phyrago An increased risk of QT interval prolongation Details Halofantrine Degarelix Injection Firmagon Increased risk of QT interval prolongation Details Halofantrine Deutetrabenazine Austedo An increased risk of QT interval prolongation Details Halofantrine Disopyramide Norpace An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Halofantrine Dofetilide Tikosyn An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Halofantrine Dolasetron Anzemet An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Halofantrine Dolasetron Injection Anzemet An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Halofantrine Encorafenib Braftovi Increased risk of QT interval prolongation Details Halofantrine Entrectinib Rozlytrek An increased risk of QT interval prolongation Details Halofantrine Flecainide Tambocor® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Halofantrine Foscarnet Injection Foscavir An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Halofantrine Fostemsavir Rukobia Increased risk of torsade de pointes Details Halofantrine Gemifloxacin Factive An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Halofantrine Glasdegib Daurismo Increased risk of QT interval prolongation Details Halofantrine Goserelin Implant Zoladex Increased risk of QT interval prolongation Details Halofantrine Granisetron Transdermal Patch Sancuso An increased risk of QT interval prolongation Details Halofantrine Granisetron Injection Granisol An increased risk of QT interval prolongation Details Halofantrine Histrelin Implant Supprelin Increased risk of QT interval prolongation Details Halofantrine Hydroxychloroquine Plaquenil An increased risk of seizures and an increased risk of QT interval prolongation Details Halofantrine Inotuzumab Ozogamicin Injection Besponsa Increased risk of QT interval prolongation Details Halofantrine Isradipine DynaCirc® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Halofantrine Ivabradine Corlanor Increased risk of QT prolongation Details Halofantrine Lefamulin Xenleta Increased risk of QT interval prolongation Details Halofantrine Lenvatinib Lenvima Increased risk of QT-interval prolongation Details Halofantrine Letermovir Injection Prevymis Increased CYP3A substrate exposure Details Halofantrine Levofloxacin Levaquin Increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.