Halofantrine

59 interactions 4 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketoconazole Topical Oxaliplatin Injection Disopyramide Dolasetron Injection Deutetrabenazine Fostemsavir
1 Contraindicated 57 Major 1 Moderate
All (59) Contraindicated (1) Major (57) Moderate (1)

Major

Halofantrine Levofloxacin Injection Levaquin Increased risk of QT interval prolongation Details Halofantrine Loperamide Diamode An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Halofantrine Mefloquine Lariam® Increased risk of QT prolongation Details Halofantrine Metronidazole Flagyl An increased risk of QT interval prolongation Details Halofantrine Metronidazole Injection Flagyl An increased risk of QT interval prolongation Details Halofantrine Metronidazole Topical MetroCream® An increased risk of QT interval prolongation Details Halofantrine Metronidazole Vaginal MetroGel® Vaginal An increased risk of QT interval prolongation Details Halofantrine Moxifloxacin Avelox Increased risk of QT interval prolongation Details Halofantrine Moxifloxacin Injection Avelox Increased risk of QT interval prolongation Details Halofantrine Moxifloxacin Ophthalmic Moxeza® Increased risk of QT interval prolongation Details Halofantrine Octreotide Bynfezia An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Halofantrine Octreotide Injection Bynfezia An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Halofantrine Ofloxacin Floxin® An increased risk of QT interval prolongation Details Halofantrine Ofloxacin Ophthalmic Ocuflox An increased risk of QT interval prolongation Details Halofantrine Ofloxacin Otic Floxin® Otic An increased risk of QT interval prolongation Details Halofantrine Olodaterol Oral Inhalation Striverdi An increased risk of QT interval prolongation and an increased risk of ventricular arrhythmias Details Halofantrine Oxaliplatin Injection Eloxatin® Increased risk of QT-interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.