Haloperidol and Metoclopramide Nasal Spray: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Haloperidol
No brand names on recordMetoclopramide Nasal Spray
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome
Interaction Deep Dive
Concomitant use of metoclopramide for injection with other drugs likely to cause extrapyramidal reactions is contraindicated2. Use of antipsychotics should be avoided in patients receiving orally administered metoclopramide due to a risk of tardive dyskinesia, other extrapyramidal symptoms, and neuroleptic malignant syndrome. If concurrent therapy is required, monitor patients closely for signs and symptoms of extrapyramidal reactions or neuroleptic malignant syndrome (fever, sweating, confusion, muscle stiffness). If symptoms occur, discontinue metoclopramide and the antipsychotic agent and manage medically 1.
Why it happens (mechanism)
Unknown
Common questions
Can I take Haloperidol and Metoclopramide Nasal Spray together?
An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Always confirm with your pharmacist or prescriber before making any change.
How serious is the Haloperidol and Metoclopramide Nasal Spray interaction?
It is rated contraindicated. These should generally not be used together.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Haloperidol or Metoclopramide Nasal Spray need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (2)
- Product Information: REGLAN(R) oral tablets, metoclopramide oral tablets. ANI Pharmaceuticals, Inc. (per FDA), Baudette, MN, 2017. DailyMed
- Product Information: Metoclopramide hydrochloride intravenous, intramuscular injection, metoclopramide hydrochloride intravenous, intramuscular injection. Fresenius Kabi (per DailyMed), Lake Zurich, IL, 2016. DailyMed
Keep reading about Haloperidol
Keep reading about Metoclopramide Nasal Spray
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