Insulin Glulisine

75 interactions 3 explained in plain English

Also sold as: Apidra

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ofloxacin Ophthalmic Miglitol Gemifloxacin Metoclopramide Nasal Spray Glipizide Moxifloxacin Injection

36 Major 39 Moderate

All (75) Major (36) Moderate (39)

Moderate

Insulin Glulisine Acebutolol Sectral® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Insulin Glulisine Benazepril Lotensin An increased risk of hypoglycemia Details Insulin Glulisine Azilsartan Edarbi Increased risk of hypoglycemia Details Insulin Glulisine Betaxolol Betoptic S Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Insulin Glulisine Betaxolol Ophthalmic Betoptic® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Insulin Glulisine Bisoprolol Zebeta® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Insulin Glulisine Candesartan Atacand Increased risk of hypoglycemia Details Insulin Glulisine Captopril Capoten® An increased risk of hypoglycemia Details Insulin Glulisine Clonidine Transdermal Patch Catapres An increased risk of hypoglycemia or hyperglycemia Details Insulin Glulisine Disopyramide Norpace Increased risk of hypoglycemia Details Insulin Glulisine Dulaglutide Injection Trulicity An increased risk of hypoglycemia Details Insulin Glulisine Enalapril Epaned An increased risk of hypoglycemia Details Insulin Glulisine Eprosartan Teveten® Increased risk of hypoglycemia Details Insulin Glulisine Esmolol Brevibloc Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Insulin Glulisine Fosinopril Monopril® An increased risk of hypoglycemia Details Insulin Glulisine Gemfibrozil Lopid An increased risk of hypoglycemia Details Insulin Glulisine Glucagon Injection Baqsimi Decreased blood glucose-lowering effects; interference with glucagon action Details Insulin Glulisine Glucagon Injection / Solution Baqsimi Decreased blood glucose-lowering effects; interference with glucagon action Details Insulin Glulisine Glucagon Nasal Powder Baqsimi Decreased blood glucose-lowering effects; interference with glucagon action Details Insulin Glulisine Irbesartan Avapro Increased risk of hypoglycemia Details Insulin Glulisine Labetalol Normodyne® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Insulin Glulisine Levobunolol Ophthalmic AKBeta® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Insulin Glulisine Levothyroxine Ermeza Worsening of glycemic control Details Insulin Glulisine Linezolid Injection Zyvox An increased risk of hypoglycemia Details Insulin Glulisine Lithium Carbonate Lithobid Hypoglycemia or hyperglycemia Details Insulin Glulisine Lixisenatide Injection Adlyxin® An increased risk of hypoglycemia Details Insulin Glulisine Losartan Arbli Increased risk of hypoglycemia Details Insulin Glulisine Mesalamine Apriso Increased risk of hypoglycemia Details Insulin Glulisine Mesalamine Rectal Canasa Increased risk of hypoglycemia Details Insulin Glulisine Moexipril Univasc® An increased risk of hypoglycemia Details Insulin Glulisine Nadolol Corgard Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Insulin Glulisine Nebivolol Bystolic Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Insulin Glulisine Olmesartan Benicar Increased risk of hypoglycemia Details Insulin Glulisine Penbutolol Levatol® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Insulin Glulisine Perindopril Aceon An increased risk of hypoglycemia Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.