Levobunolol Ophthalmic

160 interactions 263 cited references
Also sold as: AKBeta® Betagan Betagan®
About Levobunolol Ophthalmic

Ophthalmic levobunolol is used to treat glaucoma, a condition in which increased pressure in the eye can lead to gradual loss of vision. Levobunolol is in a class of medications called beta blockers. It works by decreasing the pressure in the eye. Read the full Levobunolol Ophthalmic drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

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30 Major 130 Moderate
All (160) Major (30) Moderate (130)

Moderate

Levobunolol Ophthalmic Moxisylyte An exaggerated hypotensive response to the first dose of the alpha blocker Details Levobunolol Ophthalmic Moxonidine Rebound hypertension Details Levobunolol Ophthalmic Nabumetone Relafen Reduced antihypertensive effect Details Levobunolol Ophthalmic Naproxen Aleve Reduced antihypertensive effect Details Levobunolol Ophthalmic Nateglinide Starlix® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Levobunolol Ophthalmic Nepafenac Ilevro Reduced antihypertensive effect Details Levobunolol Ophthalmic Nifedipine Adalat® An increased risk of congestive heart failure, severe hypotension or exacerbation of angina Details Levobunolol Ophthalmic Niflumic Acid Reduced antihypertensive effect Details Levobunolol Ophthalmic Nimesulide Reduced antihypertensive effect Details Levobunolol Ophthalmic Nimesulide Beta Cyclodextrin Reduced antihypertensive effect Details Levobunolol Ophthalmic Oxaprozin Coxanto Reduced antihypertensive effect Details Levobunolol Ophthalmic Oxyphenbutazone Reduced antihypertensive effect Details Levobunolol Ophthalmic Paltusotine Palsonify An increased risk of PR interval prolongation Details Levobunolol Ophthalmic Parecoxib Reduced antihypertensive effect Details Levobunolol Ophthalmic Phenoxybenzamine Dibenzyline An exaggerated hypotensive response to the first dose of the alpha blocker Details Levobunolol Ophthalmic Phentolamine An exaggerated hypotensive response to the first dose of the alpha blocker Details Levobunolol Ophthalmic Phenylbutazone Equi-Phar Reduced antihypertensive effect Details Levobunolol Ophthalmic Piketoprofen Reduced antihypertensive effect Details Levobunolol Ophthalmic Pioglitazone Actos Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Levobunolol Ophthalmic Piroxicam Feldene Reduced antihypertensive effect Details Levobunolol Ophthalmic Pramlintide Symlin Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Levobunolol Ophthalmic Pranoprofen Reduced antihypertensive effect Details Levobunolol Ophthalmic Prazosin Minipress An exaggerated hypotensive response to the first dose of the alpha blocker Details Levobunolol Ophthalmic Proglumetacin Reduced antihypertensive effect Details Levobunolol Ophthalmic Propyphenazone Reduced antihypertensive effect Details Levobunolol Ophthalmic Proquazone Reduced antihypertensive effect Details Levobunolol Ophthalmic Repaglinide Prandin® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Levobunolol Ophthalmic Rofecoxib Reduced antihypertensive effect Details Levobunolol Ophthalmic Rosiglitazone Avandia® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Levobunolol Ophthalmic Salicylic Acid Reduced antihypertensive effect Details Levobunolol Ophthalmic Salsalate Disalcid Reduced antihypertensive effect Details Levobunolol Ophthalmic Saxagliptin Onglyza Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Levobunolol Ophthalmic Sitagliptin Brynovin Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Levobunolol Ophthalmic Sodium Salicylate Reduced antihypertensive effect Details Levobunolol Ophthalmic Sulindac Clinoril® Reduced antihypertensive effect Details Levobunolol Ophthalmic Tamsulosin Flomax An exaggerated hypotensive response to the first dose of the alpha blocker Details Levobunolol Ophthalmic Tenoxicam Reduced antihypertensive effect Details Levobunolol Ophthalmic Terazosin Hytrin® An exaggerated hypotensive response to the first dose of the alpha blocker Details Levobunolol Ophthalmic Tiaprofenic Acid Reduced antihypertensive effect Details Levobunolol Ophthalmic Tolazamide Tolinase® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.