Levobunolol Ophthalmic

160 interactions 263 cited references
Also sold as: AKBeta® Betagan Betagan®
About Levobunolol Ophthalmic

Ophthalmic levobunolol is used to treat glaucoma, a condition in which increased pressure in the eye can lead to gradual loss of vision. Levobunolol is in a class of medications called beta blockers. It works by decreasing the pressure in the eye. Read the full Levobunolol Ophthalmic drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Albuterol Ceritinib Clonidine Crizotinib Darunavir Diltiazem
30 Major 130 Moderate
All (160) Major (30) Moderate (130)

Moderate

Levobunolol Ophthalmic Oxaprozin Coxanto Reduced antihypertensive effect Details Levobunolol Ophthalmic Oxyphenbutazone Reduced antihypertensive effect Details Levobunolol Ophthalmic Paltusotine Palsonify An increased risk of PR interval prolongation Details Levobunolol Ophthalmic Parecoxib Reduced antihypertensive effect Details Levobunolol Ophthalmic Phenoxybenzamine Dibenzyline An exaggerated hypotensive response to the first dose of the alpha blocker Details Levobunolol Ophthalmic Phentolamine An exaggerated hypotensive response to the first dose of the alpha blocker Details Levobunolol Ophthalmic Phenylbutazone Equi-Phar Reduced antihypertensive effect Details Levobunolol Ophthalmic Piketoprofen Reduced antihypertensive effect Details Levobunolol Ophthalmic Pioglitazone Actos Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Levobunolol Ophthalmic Piroxicam Feldene Reduced antihypertensive effect Details Levobunolol Ophthalmic Pramlintide Symlin Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Levobunolol Ophthalmic Pranoprofen Reduced antihypertensive effect Details Levobunolol Ophthalmic Prazosin Minipress An exaggerated hypotensive response to the first dose of the alpha blocker Details Levobunolol Ophthalmic Proglumetacin Reduced antihypertensive effect Details Levobunolol Ophthalmic Propyphenazone Reduced antihypertensive effect Details Levobunolol Ophthalmic Proquazone Reduced antihypertensive effect Details Levobunolol Ophthalmic Repaglinide Prandin® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Levobunolol Ophthalmic Rofecoxib Reduced antihypertensive effect Details Levobunolol Ophthalmic Rosiglitazone Avandia® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Levobunolol Ophthalmic Salicylic Acid Reduced antihypertensive effect Details Levobunolol Ophthalmic Salsalate Disalcid Reduced antihypertensive effect Details Levobunolol Ophthalmic Saxagliptin Onglyza Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Levobunolol Ophthalmic Sitagliptin Brynovin Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Levobunolol Ophthalmic Sodium Salicylate Reduced antihypertensive effect Details Levobunolol Ophthalmic Sulindac Clinoril® Reduced antihypertensive effect Details Levobunolol Ophthalmic Tamsulosin Flomax An exaggerated hypotensive response to the first dose of the alpha blocker Details Levobunolol Ophthalmic Tenoxicam Reduced antihypertensive effect Details Levobunolol Ophthalmic Terazosin Hytrin® An exaggerated hypotensive response to the first dose of the alpha blocker Details Levobunolol Ophthalmic Tiaprofenic Acid Reduced antihypertensive effect Details Levobunolol Ophthalmic Tolazamide Tolinase® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Levobunolol Ophthalmic Tolbutamide Orinase® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Levobunolol Ophthalmic Tolfenamic Acid Reduced antihypertensive effect Details Levobunolol Ophthalmic Tolmetin Tolectin 600 Reduced antihypertensive effect Details Levobunolol Ophthalmic Tranylcypromine Parnate An increased risk of more pronounced bradycardia and postural hypotension Details Levobunolol Ophthalmic Trimazosin An exaggerated hypotensive response to the first dose of the alpha blocker Details Levobunolol Ophthalmic Urapidil An exaggerated hypotensive response to the first dose of the alpha blocker Details Levobunolol Ophthalmic Valdecoxib Reduced antihypertensive effect Details Levobunolol Ophthalmic Vildagliptin Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Levobunolol Ophthalmic Yohimbine Reduced beta-adrenergic blocker effectiveness Details Levobunolol Ophthalmic Zileuton Zyflo A significant increase in beta-adrenergic blockade Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.