Levofloxacin

406 interactions 547 cited references

Also sold as: Levaquin Levaquin®

About Levofloxacin

Levofloxacin is a fluoroquinolone antibiotic used to treat bacterial infections including pneumonia, kidney, prostate, and skin infections. Read the full Levofloxacin drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Piperaquine Saquinavir Pimozide Mesoridazine Terfenadine Sparfloxacin

12 Contraindicated 297 Major 97 Moderate

All (406) Contraindicated (12) Major (297) Moderate (97)

Contraindicated

Levofloxacin Bepridil An increased risk of QT interval prolongation Details Levofloxacin Cisapride Propulsid® Increased risk of QT interval prolongation Details Levofloxacin Dronedarone Multaq Increased risk of QT interval prolongation Details Levofloxacin Levoketoconazole Recorlev An increased risk of QT interval prolongation, an increased risk of serious hepatotoxicity and drug-induced liver injury Details Levofloxacin Mesoridazine An increased risk of QT interval prolongation Details Levofloxacin Pimozide An increased risk of QT interval prolongation Details Levofloxacin Piperaquine An increased risk of QT interval prolongation Details Levofloxacin Saquinavir An increased risk of QT interval prolongation Details Levofloxacin Sparfloxacin An increased risk of QT interval prolongation Details Levofloxacin Terfenadine An increased risk of QT interval prolongation Details Levofloxacin Thioridazine An increased risk of QT interval prolongation Details Levofloxacin Ziprasidone Geodon An increased risk of QT interval prolongation Details

Major

Levofloxacin Amitriptyline Elavil Increased risk of QT interval prolongation Details Levofloxacin Sertraline An increased risk of QT interval prolongation Details Levofloxacin Buprenorphine Belbuca An increased risk of QT interval prolongation Details Levofloxacin Relugolix Orgovyx Increased risk of QT interval prolongation Details Levofloxacin Simvastatin Flolipid An increased risk of myopathy or rhabdomyolysis Details Levofloxacin Acarbose Prandase® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Levofloxacin Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Levofloxacin Arsenic Trioxide Trisenox Increased risk of QT interval prolongation Details Levofloxacin Aripiprazole Injection Abilify An increased risk of QT interval prolongation Details Levofloxacin Arsenic Trioxide Injection Trisenox Increased risk of QT interval prolongation Details Levofloxacin Asenapine Transdermal Patch Secuado Increased risk of QT interval prolongation Details Levofloxacin Azathioprine Azasan An increased risk of hepatotoxicity Details Levofloxacin Azithromycin AzaSite Increased risk of QT interval prolongation Details Levofloxacin Atorvastatin Atorvaliq An increased risk of myopathy or rhabdomyolysis Details Levofloxacin Alfuzosin UroXatral Increased risk of QT interval prolongation Details Levofloxacin Alogliptin Nesina Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Levofloxacin Anagrelide Agrylin Increased anagrelide exposure and increased risk of QT interval prolongation Details Levofloxacin Bedaquiline Sirturo Increased risk of QT interval prolongation Details Levofloxacin Budesonide Entocort An increased risk of tendon rupture Details Levofloxacin Budesonide Nasal Spray Rhinocort An increased risk of tendon rupture Details Levofloxacin Budesonide Oral Inhalation Pulmicort An increased risk of tendon rupture Details Levofloxacin Canagliflozin Invokana Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Levofloxacin Chloroquine Aralen® Increased risk of QT interval prolongation Details Levofloxacin Dapagliflozin Farxiga Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Levofloxacin Dasatinib Phyrago Increased risk of QT interval prolongation Details Levofloxacin Deflazacort Emflaza An increased risk of tendon rupture Details Levofloxacin Degarelix Injection Firmagon Increased risk of QT interval prolongation Details Levofloxacin Deutetrabenazine Austedo An increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.