Levofloxacin and Strontium Ranelate: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Levofloxacin
Strontium Ranelate
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Decreased bioavailability and exposure of strontium ranelate
Interaction Deep Dive
Concomitant use of strontium ranelate and oral quinolones is not recommended. Divalent cations, such as strontium ranelate, may form complexes with oral quinolones in the gastrointestinal tract and reduce their absorption. Discontinue strontium ranelate treatment during treatment with an oral quinolone12.
Why it happens (mechanism)
Decreased absorption of strontium ranelate by formation of complexes with oral quinolone in the gastrointestinal tract
Common questions
Can I take Levofloxacin and Strontium Ranelate together?
Decreased bioavailability and exposure of strontium ranelate Always confirm with your pharmacist or prescriber before making any change.
How serious is the Levofloxacin and Strontium Ranelate interaction?
It is rated moderate. Can be significant — usually manageable with monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Levofloxacin or Strontium Ranelate need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (2)
- Product Information: PROTELOS oral suspension, strontium ranelate oral suspension. Les Laboratoires Servier (per EMA), Suresnes, France, 2012.
- Product Information: OSSEOR oral suspension, strontium ranelate oral suspension. Les Laboratories Servier (per EMA), Suresnes, France, 2012.
Keep reading about Levofloxacin
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