Lumefantrine

113 interactions 7 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Acetaminophen And Codeine Levofloxacin Oxaliplatin Injection Aripiprazole Injection Flecainide Dolasetron

75 Major 38 Moderate

All (113) Major (75) Moderate (38)

Moderate

Lumefantrine Bexarotene Targretin Reduced artemether/lumefantrine exposure, reduced efficacy of artemether/lumefantrine and loss of antimalarial efficacy Details Lumefantrine Bexarotene Topical Targretin Reduced artemether/lumefantrine exposure, reduced efficacy of artemether/lumefantrine and loss of antimalarial efficacy Details Lumefantrine Brigatinib Alunbrig Reduced artemether/lumefantrine exposure, reduced efficacy of artemether/lumefantrine and loss of antimalarial efficacy Details Lumefantrine Brivaracetam Briviact Reduced artemether/lumefantrine exposure, reduced efficacy of artemether/lumefantrine and loss of antimalarial efficacy Details Lumefantrine Brivaracetam Injection Briviact Reduced artemether/lumefantrine exposure, reduced efficacy of artemether/lumefantrine and loss of antimalarial efficacy Details Lumefantrine Brodalumab Injection Siliq Increased artemether/lumefantrine exposure and an increased risk of potentiated QT prolongation Details Lumefantrine Clotrimazole Aardora Anti-Fungal Maximum Strength Increased artemether/lumefantrine exposure and an increased risk of potentiated QT prolongation Details Lumefantrine Clotrimazole Lozenge Mycelex® Increased artemether/lumefantrine exposure and an increased risk of potentiated QT prolongation Details Lumefantrine Clotrimazole Topical Cruex Antifungal Increased artemether/lumefantrine exposure and an increased risk of potentiated QT prolongation Details Lumefantrine Clotrimazole Vaginal Gyne-Lotrimin 3® Cream Increased artemether/lumefantrine exposure and an increased risk of potentiated QT prolongation Details Lumefantrine Cyclosporine Injection Atopica Increased artemether/lumefantrine exposure and an increased risk of potentiated QT prolongation Details Lumefantrine Cyclosporine Ophthalmic Cequa Increased artemether/lumefantrine exposure and an increased risk of potentiated QT prolongation Details Lumefantrine Darolutamide Nubeqa Reduced artemether/lumefantrine exposure, reduced efficacy of artemether/lumefantrine and loss of antimalarial efficacy Details Lumefantrine Dexamethasone Injection Decadron Reduced artemether/lumefantrine exposure, reduced efficacy of artemether/lumefantrine and loss of antimalarial efficacy Details Lumefantrine Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Reduced artemether/lumefantrine exposure, reduced efficacy of artemether/lumefantrine and loss of antimalarial efficacy Details Lumefantrine Enasidenib Idhifa Reduced artemether/lumefantrine exposure, reduced efficacy of artemether/lumefantrine and loss of antimalarial efficacy Details Lumefantrine Erdafitinib Balversa Increased artemether/lumefantrine exposure and an increased risk of potentiated QT prolongation Details Lumefantrine Esketamine Nasal Spray Spravato Increased artemether/lumefantrine exposure and an increased risk of potentiated QT prolongation Details Lumefantrine Esomeprazole Nexium Increased artemether/lumefantrine exposure and an increased risk of potentiated QT prolongation Details Lumefantrine Esomeprazole Injection Nexium Increased artemether/lumefantrine exposure and an increased risk of potentiated QT prolongation Details Lumefantrine Everolimus Afinitor Increased artemether/lumefantrine exposure and an increased risk of potentiated QT prolongation Details Lumefantrine Fostamatinib Tavalisse Increased artemether/lumefantrine exposure and an increased risk of potentiated QT prolongation Details Lumefantrine Ibrexafungerp Brexafemme Increased artemether/lumefantrine exposure and an increased risk of potentiated QT prolongation Details Lumefantrine Istradefylline Nourianz Increased artemether/lumefantrine exposure and an increased risk of potentiated QT prolongation Details Lumefantrine Lanthanum Fosrenol® Reduced bioavailability of antimalarials Details Lumefantrine Lenacapavir Injection Sunlenca Increased artemether/lumefantrine exposure and an increased risk of potentiated QT prolongation Details Lumefantrine Lenacapavir Oral Sunlenca Increased artemether/lumefantrine exposure and an increased risk of potentiated QT prolongation Details Lumefantrine Linagliptin Tradjenta Increased artemether/lumefantrine exposure and an increased risk of potentiated QT prolongation Details Lumefantrine Lumateperone Caplyta Increased artemether/lumefantrine exposure and an increased risk of potentiated QT prolongation Details Lumefantrine Lurasidone Latuda Increased artemether/lumefantrine exposure and an increased risk of potentiated QT prolongation Details Lumefantrine Mitapivat Aqvesme Reduced artemether/lumefantrine exposure, reduced efficacy of artemether/lumefantrine and loss of antimalarial efficacy Details Lumefantrine Nafcillin Injection Unipen® Injection Reduced artemether/lumefantrine exposure, reduced efficacy of artemether/lumefantrine and loss of antimalarial efficacy Details Lumefantrine Olaparib Lynparza Increased artemether/lumefantrine exposure and an increased risk of potentiated QT prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.