Mavorixafor and Aripiprazole Injection: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Jul 11, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Mavorixafor
Aripiprazole Injection
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased CYP2D6 substrate exposure, increased risk of CYP2D6-related adverse events and an increased risk of QT interval prolongation and torsade de pointes
Interaction Deep Dive
Coadministration of mavorixafor (CYP2D6 inhibitor) with drugs that are highly dependent on CYP2D6 for clearance is contraindicated. Concomitant use of mavorixafor with CYP2D6 substrates may increase CYP2D6 substrates exposure and may increase the risk of CYP2D6-related adverse reactions. Additionally, concomitant use of mavorixafor with CYP2D6 substrates that prolong the QT interval increases the risk of QT prolongation including torsade de pointes, other serious arrhythmias and sudden death. Consider obtaining electrocardiograms, correct any modifiable risk factors for QT prolongation and monitor patients during coadministration. A dose reduction or discontinuation of mavorixafor may be required. In a drug interaction study, coadministration of mavorixafor 400 mg with dextromethorphan (CYP2D6 substrate) in healthy subjects resulted in 6-fold and 9-fold increase in Cmax and AUC, respectively1.
Why it happens (mechanism)
Inhibition of CYP2D6-mediated metabolism by mavorixafor; additive QT interval prolongation
Literature reports
1 report — tap to read
a) In a drug interaction study, coadministration of mavorixafor (CYP2D6 inhibitor) 400 mg with dextromethorphan (CYP2D6 substrate) in healthy subjects resulted in 6-fold and 9-fold increase in Cmax and AUC, respectively 1.
Common questions
Can I take Mavorixafor and Aripiprazole Injection together?
Increased CYP2D6 substrate exposure, increased risk of CYP2D6-related adverse events and an increased risk of QT interval prolongation and torsade de pointes Always confirm with your pharmacist or prescriber before making any change.
How serious is the Mavorixafor and Aripiprazole Injection interaction?
It is rated contraindicated. These should generally not be used together.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
Questions for your pharmacist
- Does my dose of Mavorixafor or Aripiprazole Injection need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: XOLREMDI(TM) oral capsules, mavorixafor oral capsules. X4 Pharmaceuticals, Inc. (Per FDA), Boston, MA, 2024. DailyMed
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