Medroxyprogesterone

108 interactions 317 cited references
Also sold as: Amen® Curretab® Cycrin® Depo-Provera depo-subQ provera Prodroxy® Provera Provera®
About Medroxyprogesterone

A progestin hormone medication used to treat abnormal bleeding and regulate menstrual periods in women. Read the full Medroxyprogesterone drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Medroxyprogesterone Isotretinoin Absorica Decreased effectiveness of hormonal contraceptives Details Medroxyprogesterone Bexarotene Targretin Decreased contraceptive effectiveness Details Medroxyprogesterone Bexarotene Topical Targretin Decreased contraceptive effectiveness Details Medroxyprogesterone Dexamethasone Injection Decadron Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive, increased risk of breakthrough bleeding and/o... Details Medroxyprogesterone Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive, increased risk of breakthrough bleeding and/o... Details Medroxyprogesterone Enasidenib Idhifa Reduced hormonal contraceptive exposure and reduced efficacy of hormonal contraceptive and an increased risk of breakthrough bleed... Details Medroxyprogesterone Encorafenib Braftovi Reduced hormonal contraceptives exposure and reduced efficacy of hormonal contraceptives Details Medroxyprogesterone Finerenone Kerendia Increased finerenone exposure and an increased risk of finerenone-related adverse effects Details Medroxyprogesterone Loperamide Diamode Increased loperamide exposure and an increased risk of loperamide-related adverse effects Details Medroxyprogesterone Adenovirus Vaccine Type 4, Live An increased risk of infection by the live vaccine Details Medroxyprogesterone Adenovirus Vaccine Type 7, Live An increased risk of infection by the live vaccine Details Medroxyprogesterone Alfentanil Increased ALfentanil exposure, an increased risk of ALfentanil-related adverse reactions and/or prolonged effects, which may exace... Details Medroxyprogesterone Apalutamide Erleada Reduced medroxyPROGESTERone exposure Details Medroxyprogesterone Aprepitant Aponvie Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and an increased risk of breakthrough bleedin... Details Medroxyprogesterone Armodafinil Nuvigil Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and increased risk of breakthrough bleeding a... Details Medroxyprogesterone Belzutifan Welireg An increased belzutifan exposure, an increased risk of belzutifan-related adverse effects, reduced hormonal contraceptives exposur... Details Medroxyprogesterone Bosentan Reduced medroxyPROGESTERone exposure Details Medroxyprogesterone Carbamazepine Carbatrol Reduced medroxyPROGESTERone exposure Details Medroxyprogesterone Cenobamate Xcopri Reduced medroxyPROGESTERone exposure Details Medroxyprogesterone Cholera Vaccine Ipol An increased risk of infection by the live vaccine Details Medroxyprogesterone Clobazam Onfi Decreased contraceptive effectiveness Details Medroxyprogesterone Clomipramine Anafranil Increased clomiPRAMINE exposure and an attenuation of antidepressant effectiveness; tricyclic toxicity (drowsiness, hypotension, a... Details Medroxyprogesterone Dabrafenib Tafinlar Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and increased risk of breakthrough bleeding a... Details Medroxyprogesterone Darunavir Reduced hormonal contraceptives exposure, reduced efficacy of hormonal contraceptives and an increased darunavir exposure Details Medroxyprogesterone Dexamethasone Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive, increased risk of breakthrough bleeding and/o... Details Medroxyprogesterone Dextroamphetamine Dexedrine Increased dextroamphetamine or lisdexamfetamine (prodrug of dextroamphetamine) exposure and an increased risk of serotonin syndrom... Details Medroxyprogesterone Ebola Zaire Vaccine, Live An increased risk of infection by the live vaccine Details Medroxyprogesterone Efavirenz Reduced medroxyPROGESTERone exposure Details Medroxyprogesterone Elafibranor Iqirvo Reduced hormonal contraceptives exposure, reduced efficacy of hormonal contraceptives and/or an increased risk of breakthrough ble... Details Medroxyprogesterone Elagolix Orilissa Increased estrogen exposure, reduced progestin efficacy, and reduced elagolix efficacy Details Medroxyprogesterone Elvitegravir Altered contraceptive effectiveness and risk of side effects Details Medroxyprogesterone Enzalutamide Xtandi Reduced medroxyPROGESTERone exposure Details Medroxyprogesterone Erythromycin Erythrocin Stearate Increased CYP3A4 substrate exposure and an increased risk of CYP3A4-substrate-related adverse effects Details Medroxyprogesterone Eslicarbazepine Acetate Aptiom Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and increased risk of breakthrough bleeding a... Details Medroxyprogesterone Etravirine Intelence Reduced medroxyPROGESTERone exposure Details Medroxyprogesterone Fosaprepitant Emend Injection Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and an increased risk of breakthrough bleedin... Details Medroxyprogesterone Fosphenytoin Cerebyx Reduced medroxyPROGESTERone exposure Details Medroxyprogesterone Griseofulvin Fulvicin P/G Decreased contraceptive effectiveness Details Medroxyprogesterone Influenza Virus Vaccine, Live An increased risk of infection by the live vaccine Details Medroxyprogesterone Ivosidenib Tibsovo Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and increased risk of breakthrough bleeding a... Details

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