Medroxyprogesterone

108 interactions 317 cited references
Also sold as: Amen® Curretab® Cycrin® Depo-Provera depo-subQ provera Prodroxy® Provera Provera®
About Medroxyprogesterone

A progestin hormone medication used to treat abnormal bleeding and regulate menstrual periods in women. Read the full Medroxyprogesterone drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Medroxyprogesterone Lemborexant Dayvigo Increased lemborexant exposure and an increased risk of lemborexant-related adverse reactions. Details Medroxyprogesterone Lesinurad Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive and increased risk of breakthrough bleeding an... Details Medroxyprogesterone Lisdexamfetamine Arynta Increased dextroamphetamine or lisdexamfetamine (prodrug of dextroamphetamine) exposure and an increased risk of serotonin syndrom... Details Medroxyprogesterone Lorlatinib Lorbrena Reduced medroxyPROGESTERone exposure Details Medroxyprogesterone Lumacaftor Reduced medroxyPROGESTERone exposure Details Medroxyprogesterone Mavacamten Camzyos Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive, increased mavacamten exposure and an increase... Details Medroxyprogesterone Melatonin Increased melatonin exposure Details Medroxyprogesterone Meropenem Reduced hormonal contraceptive exposure and an increased risk of contraceptive failure Details Medroxyprogesterone Methylergonovine Methergine Increased methylergonovine exposure Details Medroxyprogesterone Mifepristone Korlym Reduced hormonal contraceptive exposure, an increased miFEPRIStone exposure and an increased hormonal contraceptives exposure Details Medroxyprogesterone Mitapivat Aqvesme Reduced hormonal contraceptive exposure Details Medroxyprogesterone Mitotane Lysodren Reduced medroxyPROGESTERone exposure Details Medroxyprogesterone Mobocertinib Exkivity Reduced exposure of the hormonal contraceptive, which may result in reduced contraceptive efficacy and an increased risk of breakt... Details Medroxyprogesterone Modafinil Provigil Reduced medroxyPROGESTERone exposure Details Medroxyprogesterone Mycophenolic Acid Myfortic Decreased contraceptive efficacy Details Medroxyprogesterone Nafcillin Reduced medroxyPROGESTERone exposure Details Medroxyprogesterone Nevirapine Viramune Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and increased risk of breakthrough bleeding a... Details Medroxyprogesterone Nifedipine Adalat® Increased NIFEdipine exposure Details Medroxyprogesterone Omaveloxolone Skyclarys Reduced hormonal contraceptive exposure, reduced efficacy of contraceptive and an increased risk of breakthrough bleeding/contrace... Details Medroxyprogesterone Oxcarbazepine Oxtellar Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and increased risk of contraceptive failure Details Medroxyprogesterone Pacritinib Vonjo® Reduced efficacy of hormonal contraceptives Details Medroxyprogesterone Phenobarbital Fidoquel Reduced medroxyPROGESTERone exposure Details Medroxyprogesterone Phenylbutazone Equi-Phar Reduced contraceptive exposure, reduced efficacy of hormonal contraceptives and an increased risk of breakthrough bleeding and/or... Details Medroxyprogesterone Phenytoin Dilantin Reduced medroxyPROGESTERone exposure Details Medroxyprogesterone Pimozide Increased pimozide exposure and an increased risk of pimozide-related adverse reactions Details Medroxyprogesterone Pitolisant Wakix Reduced efficacy of hormonal contraceptives Details Medroxyprogesterone Prednisone Deltasone Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive and increased predniSONE exposure and an incre... Details Medroxyprogesterone Primidone Mysoline Reduced medroxyPROGESTERone exposure Details Medroxyprogesterone Red Clover Altered contraceptive effectiveness or increased side effects Details Medroxyprogesterone Repotrectinib Augtyro Reduced hormonal contraceptive exposure, reduced effectiveness of hormonal contraceptive and an increased risk of breakthrough ble... Details Medroxyprogesterone Rifabutin Mycobutin Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and increased risk of breakthrough bleeding a... Details Medroxyprogesterone Rifampin Rifadin Reduced medroxyPROGESTERone exposure Details Medroxyprogesterone Rifapentine Priftin Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and increased risk of breakthrough bleeding a... Details Medroxyprogesterone Ritonavir Norvir Reduced estrogen/progestin exposure and reduced efficacy of contraceptive Details Medroxyprogesterone Rotavirus Vaccine, Live An increased risk of infection by the live vaccine Details Medroxyprogesterone Rufinamide Banzel Reduced contraceptive exposure, reduced efficacy of combination contraceptives and an increased risk of breakthrough bleeding/cont... Details Medroxyprogesterone Secobarbital Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive and an increased risk of breakthrough bleeding... Details Medroxyprogesterone St John's Wort Reduced medroxyPROGESTERone exposure Details Medroxyprogesterone Sugammadex Decreased contraceptive serum concentration and efficacy Details Medroxyprogesterone Sunvozertinib Zegfrovy Reduced hormonal contraceptives exposure and reduced efficacy of hormonal contraceptives Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.