Mesalamine

115 interactions 274 cited references
Also sold as: Apriso Apriso® Asacol HD® Asacol® Canasa Delzicol Delzicol® Lialda Lialda® Pentasa Pentasa® Rowasa
About Mesalamine

Mesalamine is an anti-inflammatory medication used to treat ulcerative colitis and reduce swelling and sores in the colon and rectum. Read the full Mesalamine drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Probenecid Methotrexate Injection Ibuprofen Diclofenac Ophthalmic Amtolmetin Guacil Acemetacin
1 Contraindicated 86 Major 28 Moderate
All (115) Contraindicated (1) Major (86) Moderate (28)

Major

Mesalamine Azathioprine Azasan An increased risk of myelosuppression, an increased risk of hepatotoxicity and an increased risk of blood disorders Details Mesalamine Bromfenac Ophthalmic Bromday® Increased risk of bleeding Details Mesalamine Diclofenac Ophthalmic Voltaren® Eye Drops Increased risk of bleeding Details Mesalamine Diclofenac Topical (Actinic Keratosis) Pennsaid Increased risk of bleeding Details Mesalamine Diclofenac Topical (Arthritis Pain) Pennsaid® Increased risk of bleeding Details Mesalamine Diclofenac Transdermal Patch Flector Increased risk of bleeding Details Mesalamine Etodolac Lodine Increased risk of bleeding Details Mesalamine Fenoprofen Fenopron Increased risk of bleeding Details Mesalamine Flurbiprofen Ansaid Increased risk of bleeding Details Mesalamine Flurbiprofen Ophthalmic Ocufen Increased risk of bleeding Details Mesalamine Hydrocortisone Ala-Cort An increased risk of gastrointestinal adverse reactions, reduced salicylate exposure and an increased risk of salicylate toxicity... Details Mesalamine Hydrocortisone Injection A-Hydrocort® An increased risk of gastrointestinal adverse reactions, reduced salicylate exposure and an increased risk of salicylate toxicity... Details Mesalamine Ibuprofen Addaprin An increased risk of gastrointestinal toxicity Details Mesalamine Ketoprofen Actron® Increased risk of bleeding Details Mesalamine Meclofenamate Meclodium® Increased risk of bleeding Details Mesalamine Mefenamic Acid Ponstel® Increased risk of bleeding Details Mesalamine Meloxicam Alloxate An increased risk of gastrointestinal toxicity and an increased risk of bleeding Details Mesalamine Meloxicam Injection Alloxate An increased risk of gastrointestinal toxicity and an increased risk of bleeding Details Mesalamine Mercaptopurine Purinethol® An increased risk of myelosuppression, an increased risk of hepatotoxicity and an increased risk of blood disorders Details Mesalamine Aceclofenac Increased risk of bleeding Details Mesalamine Acemetacin Increased risk of bleeding Details Mesalamine Amtolmetin Guacil Increased risk of bleeding Details Mesalamine Balsalazide Colazal Increased risk of bleeding Details Mesalamine Bismuth Subsalicylate Bismarex Increased risk of bleeding Details Mesalamine Bromfenac Bromsite Increased risk of bleeding Details Mesalamine Bufexamac Increased risk of bleeding Details Mesalamine Celecoxib Celebrex An increased risk of GI toxicity and an increased risk of bleeding Details Mesalamine Choline Magnesium Trisalicylate Trilisate® Increased risk of bleeding Details Mesalamine Choline Salicylate Increased risk of bleeding Details Mesalamine Clonixin Increased risk of bleeding Details Mesalamine Dexibuprofen Increased risk of bleeding Details Mesalamine Dexketoprofen Increased risk of bleeding Details Mesalamine Diclofenac Aleve Arthritis Pain Increased risk of bleeding Details Mesalamine Diflunisal Dolobid Increased risk of bleeding Details Mesalamine Dipyrone Increased risk of bleeding Details Mesalamine Droxicam Increased risk of bleeding Details Mesalamine Etofenamate Increased risk of bleeding Details Mesalamine Etoricoxib Increased risk of bleeding Details Mesalamine Felbinac Increased risk of bleeding Details Mesalamine Fepradinol Increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.