Mesalamine

115 interactions 274 cited references

Also sold as: Apriso Apriso® Asacol HD® Asacol® Canasa Delzicol Delzicol® Lialda Lialda® Pentasa Pentasa® Rowasa

About Mesalamine

Mesalamine is an anti-inflammatory medication used to treat ulcerative colitis and reduce swelling and sores in the colon and rectum. Read the full Mesalamine drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Probenecid Methotrexate Injection Ibuprofen Diclofenac Ophthalmic Amtolmetin Guacil Acemetacin

1 Contraindicated 86 Major 28 Moderate

All (115) Contraindicated (1) Major (86) Moderate (28)

Major

Mesalamine Feprazone Increased risk of bleeding Details Mesalamine Floctafenine Increased risk of bleeding Details Mesalamine Flufenamic Acid Increased risk of bleeding Details Mesalamine Fosphenytoin Cerebyx Increased phenytoin or fosphenytoin (prodrug of phenytoin) exposure and an increased risk of phenytoin or fosphenytoin toxicity Details Mesalamine Indomethacin Indocin Increased risk of bleeding Details Mesalamine Insulin Icodec-Abae Awiqli An increased risk of hypoglycemia Details Mesalamine Levoketoconazole Recorlev Increased risk of serious hepatotoxicity and drug-induced liver injury Details Mesalamine Lornoxicam Increased risk of bleeding Details Mesalamine Loxoprofen Increased risk of bleeding Details Mesalamine Lumiracoxib Increased risk of bleeding Details Mesalamine Magnesium Salicylate Increased risk of bleeding Details Mesalamine Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Mesalamine Morniflumate Increased risk of bleeding Details Mesalamine Nabumetone Relafen Increased risk of bleeding Details Mesalamine Naproxen Aleve Increased risk of bleeding Details Mesalamine Nepafenac Ilevro Increased risk of bleeding Details Mesalamine Niflumic Acid Increased risk of bleeding Details Mesalamine Nimesulide Increased risk of bleeding Details Mesalamine Nimesulide Beta Cyclodextrin Increased risk of bleeding Details Mesalamine Olsalazine Dipentum Increased risk of bleeding Details Mesalamine Oxaprozin Coxanto Increased risk of bleeding Details Mesalamine Oxyphenbutazone Increased risk of bleeding Details Mesalamine Parecoxib Increased risk of bleeding Details Mesalamine Phenylbutazone Equi-Phar Increased risk of bleeding Details Mesalamine Phenyl Salicylate Increased risk of bleeding Details Mesalamine Phenytoin Dilantin Increased phenytoin or fosphenytoin (prodrug of phenytoin) exposure and an increased risk of phenytoin or fosphenytoin toxicity Details Mesalamine Piketoprofen Increased risk of bleeding Details Mesalamine Piroxicam Feldene Increased risk of bleeding Details Mesalamine Proglumetacin Increased risk of bleeding Details Mesalamine Propyphenazone Increased risk of bleeding Details Mesalamine Proquazone Increased risk of bleeding Details Mesalamine Rofecoxib Increased risk of bleeding Details Mesalamine Salicylamide Increased risk of bleeding Details Mesalamine Salicylic Acid Increased risk of bleeding Details Mesalamine Salsalate Disalcid Increased risk of bleeding Details Mesalamine Sodium Salicylate Increased risk of bleeding Details Mesalamine Sulfasalazine Azulfidine Increased risk of bleeding Details Mesalamine Sulindac Clinoril® Increased risk of bleeding Details Mesalamine Tenoxicam Increased risk of bleeding Details Mesalamine Tiaprofenic Acid Increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.