Metipranolol

58 interactions 2 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Albuterol Oral Inhalation Clonidine Transdermal Patch Indacaterol Oral Inhalation Lacosamide Injection Methylergonovine Olodaterol Oral Inhalation

6 Major 52 Moderate

All (58) Major (6) Moderate (52)

Moderate

Metipranolol Acarbose Prandase® Explained Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Metipranolol Asenapine Transdermal Patch Secuado An increased risk of hypotension Details Metipranolol Aspirin Acuprin® Reduced antihypertensive effect Details Metipranolol Aspirin Rectal Aspirin Reduced antihypertensive effect Details Metipranolol Alfuzosin UroXatral An exaggerated hypotensive response to the first dose of the alpha blocker Details Metipranolol Alogliptin Nesina Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Metipranolol Bromfenac Ophthalmic Bromday® Reduced antihypertensive effect Details Metipranolol Canagliflozin Invokana Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Metipranolol Dapagliflozin Farxiga Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Metipranolol Diclofenac Ophthalmic Voltaren® Eye Drops Reduced antihypertensive effect Details Metipranolol Diclofenac Topical (Actinic Keratosis) Pennsaid Reduced antihypertensive effect Details Metipranolol Diclofenac Topical (Arthritis Pain) Pennsaid® Reduced antihypertensive effect Details Metipranolol Diclofenac Transdermal Patch Flector Reduced antihypertensive effect Details Metipranolol Digoxin Cardoxin® Increased risk of bradycardia and possible digitalis glycoside toxicity Details Metipranolol Doxazosin Cardura An exaggerated hypotensive response to the first dose of the alpha blocker Details Metipranolol Dulaglutide Injection Trulicity Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Metipranolol Empagliflozin Glyxambi® (as a combination product containing Empagliflozin and Linagliptin) Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Metipranolol Ertugliflozin Steglatro Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Metipranolol Etodolac Lodine Reduced antihypertensive effect Details Metipranolol Exenatide Injection Bydureon Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Metipranolol Fenoprofen Fenopron Reduced antihypertensive effect Details Metipranolol Flurbiprofen Ansaid Reduced antihypertensive effect Details Metipranolol Flurbiprofen Ophthalmic Ocufen Reduced antihypertensive effect Details Metipranolol Glimepiride Amaryl Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Metipranolol Glipizide Glucotrol Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Metipranolol Glucagon Injection Baqsimi A transient increase in pulse and blood pressure Details Metipranolol Glucagon Injection / Solution Baqsimi A transient increase in pulse and blood pressure Details Metipranolol Glucagon Nasal Powder Baqsimi A transient increase in pulse and blood pressure Details Metipranolol Ibuprofen Addaprin Reduced antihypertensive effect Details Metipranolol Insulin Degludec (Rdna Origin) Injection Ryzodeg® (as a combination product containing Insulin Degludec and Insulin Aspart) Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Metipranolol Insulin Detemir (Rdna Origin) Injection Levemir Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Metipranolol Insulin Glulisine (Rdna Origin) Injection Apidra Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Metipranolol Ketoprofen Actron® Reduced antihypertensive effect Details Metipranolol Ketorolac Acular Reduced antihypertensive effect Details Metipranolol Ketorolac Injection Acular Reduced antihypertensive effect Details Metipranolol Ketorolac Nasal Spray Sprix Reduced antihypertensive effect Details Metipranolol Ketorolac Ophthalmic Acular Reduced antihypertensive effect Details Metipranolol Linagliptin Tradjenta Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Metipranolol Liraglutide Injection Saxenda Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Metipranolol Lixisenatide Injection Adlyxin® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details

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