Midostaurin and Elinzanetant: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Midostaurin
Elinzanetant
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased CYP3A4 substrate with NTI exposure and an increased CYP3A4 substrate with NTI-related adverse reactions
Interaction Deep Dive
Avoid concomitant use of elinzanetant (weak CYP3A4 inhibitor) with CYP3A4 substrates where minimal concentration changes may lead to serious adverse reactions. Concomitant use of elinzanetant increases exposure of CYP3A4 substrates, which may increase the risk of adverse reactions related to these substrates1.
Why it happens (mechanism)
Inhibition of CYP3A4-substrate metabolism by elinzanetant
Literature reports
1 report — tap to read
a) In a drug interaction study, coadministration of elinzanetant with midazolam increased midazolam (sensitive CYP3A4 substrate) Cmax 1.5-fold and AUC 1.8-fold 1.
Common questions
Can I take Midostaurin and Elinzanetant together?
Increased CYP3A4 substrate with NTI exposure and an increased CYP3A4 substrate with NTI-related adverse reactions Always confirm with your pharmacist or prescriber before making any change.
How serious is the Midostaurin and Elinzanetant interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Midostaurin or Elinzanetant need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: LYNKUET® oral capsules, elinzanetant oral capsules. Bayer HealthCare Pharmaceuticals Inc (per Manufacturer), Whippany, NJ, 2025. DailyMed
Keep reading about Midostaurin
Keep reading about Elinzanetant
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