Mitapivat and Zoliflodacin: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Mitapivat
Zoliflodacin
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Reduced zoliflodacin exposure and reduced efficacy of zoliflodacin
Interaction Deep Dive
Concomitant use of zoliflodacin (CYP3A4 substrate) with moderate or strong CYP3A4 inducers is contraindicated as it may reduce zoliflodacin exposure and thus may reduce efficacy of zoliflodacin1.
Why it happens (mechanism)
Induction of CYP3A4-mediated metabolism of zoliflodacin
Literature reports
1 report — tap to read
a) In a drug interaction study, coadministration of zoliflodacin with CYP3A4 inducers, rifAMPin and efavirenz, is predicted to reduce the geometric mean zoliflodacin exposure, AUC (0 to inf) by approximately 56 and 41%, respectively 1.
Common questions
Can I take Mitapivat and Zoliflodacin together?
Reduced zoliflodacin exposure and reduced efficacy of zoliflodacin Always confirm with your pharmacist or prescriber before making any change.
How serious is the Mitapivat and Zoliflodacin interaction?
It is rated contraindicated. These should generally not be used together.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Mitapivat or Zoliflodacin need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: NUZOLVENCE® granules for oral suspension, zoliflodacin granules for oral suspension. La Jolla Pharmaceutical Company, Waltham, MA, 2025. DailyMed
Keep reading about Mitapivat
Keep reading about Zoliflodacin
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