Mobocertinib and Medroxyprogesterone: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Mobocertinib
Medroxyprogesterone
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Reduced exposure of the hormonal contraceptive, which may result in reduced contraceptive efficacy and an increased risk of breakthrough bleeding/contraceptive failure
Interaction Deep Dive
Avoid coadministration of mobocertinib with hormonal contraceptives1 as it may reduce of the contraceptive exposure, which may lead to reduced contraceptive efficacy. Advise females of reproductive potential to use effective non-hormonal contraception during treatment with mobocertinib and for 1 month after the last dose. Advise males with female partners of reproductive potential to use effective contraception during treatment with mobocertinib and for 1 week after the last dose of mobocertinib 2.
Why it happens (mechanism)
Induction of the metabolism of the hormonal contraceptive by mobocertinib
Common questions
Can I take Mobocertinib and Medroxyprogesterone together?
Reduced exposure of the hormonal contraceptive, which may result in reduced contraceptive efficacy and an increased risk of breakthrough bleeding/contraceptive failure Always confirm with your pharmacist or prescriber before making any change.
How serious is the Mobocertinib and Medroxyprogesterone interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Mobocertinib or Medroxyprogesterone need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (2)
- Product Information: FEMLYV orally disintegrating tablets, norethindrone acetate, ethinyl estradiol orally disintegrating tablets. Millicent U.S. Inc (per FDA), East Hanover, NJ, 2024. DailyMed
- Product Information: EXKIVITY(TM) oral capsules, mobocertinib oral capsules. Takeda Pharmaceuticals America Inc (per FDA), Lexington, MA, 2021.
Keep reading about Mobocertinib
Keep reading about Medroxyprogesterone
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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