Drug Interaction Report

Moxalactam and Heparin Injection: Interaction Details

A pharmacist-reviewed analysis of the Moxalactam and Heparin Injection interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Heparin Injection

Lipo-Hepin® Liquaemin® Panheparin®
+

Moxalactam

No brand names on record
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
Updated Aug 8, 2026
Editorial policy · Data sources
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Interaction severity
Major
Potentially serious — often needs a change or close monitoring.
How we grade severity & evidence

Severity levels

  • Contraindicated: These should generally not be used together.
  • Major: Potentially serious — often needs a change or close monitoring.
  • Moderate: Can be significant — usually manageable with monitoring.
  • Minor: Usually limited clinical impact.

Evidence grades

  • Established: Well documented — supported by controlled studies or strong clinical data.
  • Probable: Good supporting evidence, though not definitively proven.
  • Suspected: Some evidence suggests this interaction, but it is not well established.
  • Possible: Limited or conflicting evidence; the interaction may occur.
  • Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Worried about symptoms right now? Contact your pharmacist or prescriber, or call Poison Control at 1-800-222-1222 (US). Call 911 for an emergency.
Onset
delayed
Evidence
theoretical
Severity
Major

What happens

Increased risk of bleeding

Interaction Deep Dive

Compared to the other cephalosporins, coagulation abnormalities are most commonly reported with moxalactam, cefamandole, and cefoperazone, possibly due to a direct effect on prothrombin time or vitamin K production12.

Why it happens (mechanism)

Inhibition of platelet function, decreased clotting factor synthesis

Common questions

Can I take Moxalactam and Heparin Injection together?

Increased risk of bleeding Always confirm with your pharmacist or prescriber before making any change.

How serious is the Moxalactam and Heparin Injection interaction?

It is rated major. Potentially serious — often needs a change or close monitoring.

How quickly could this interaction happen?

The documented onset is "delayed". Effects tend to build up gradually over days to weeks.

How strong is the evidence for this interaction?

The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.

Questions for your pharmacist

  • Does my dose of Moxalactam or Heparin Injection need adjusting while I take them together?
  • What symptoms should prompt me to call you or my prescriber right away?
  • Does the timing of my doses matter for this combination?
  • Is there a safer alternative to one of these medications for me?

References (2)

  1. Parker SW, Baxter J, & Beam TR Jr: Cefoperazone-induced coagulopathy (Letter). Lancet 1984; 1:1016. PubMed
  2. Cristiano P: Hypoprothrombinemia associated with cefoperazone treatment. Drug Intell Clin Pharm 1984; 18:314-316. PubMed
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Heparin Injection

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Moxalactam

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