Nafcillin Injection and Omaveloxolone: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Omaveloxolone
Nafcillin Injection
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Reduced omaveloxolone exposure and reduced efficacy of omaveloxolone
Interaction Deep Dive
Avoid concomitant use of omaveloxolone with strong or moderate CYP3A4 inducers. Concomitant use of omaveloxolone with a strong or moderate CYP3A4 inducer may significantly reduce omaveloxolone exposure, which may reduce the effectiveness of omaveloxolone. In a drug interaction study, after single dose administration, omaveloxolone Cmax and AUC decreased 38% and 48%, respectively, following concomitant use with efavirenz (moderate CYP3A4 inducer)1.
Why it happens (mechanism)
Induction of CYP3A4-mediated metabolism of omaveloxolone
Literature reports
1 report — tap to read
a) In a drug interaction study, after single dose administration, omaveloxolone Cmax and AUC decreased 38% and 48%, respectively, following concomitant use with efavirenz (moderate CYP3A4 inducer) 1.
Common questions
Can I take Nafcillin Injection and Omaveloxolone together?
Reduced omaveloxolone exposure and reduced efficacy of omaveloxolone Always confirm with your pharmacist or prescriber before making any change.
How serious is the Nafcillin Injection and Omaveloxolone interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
Questions for your pharmacist
- Does my dose of Nafcillin Injection or Omaveloxolone need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: Skyclarys® oral capsules, omaveloxolone oral capsules. Biogen U.S. Corporation, Cambridge, MA, 2026. DailyMed
Keep reading about Omaveloxolone
Keep reading about Nafcillin Injection
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major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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