Drug Interaction Report

Nifedipine and Micafungin: Interaction Details

A pharmacist-reviewed analysis of the Nifedipine and Micafungin interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Nifedipine

Adalat® Adalat® CC Afeditab CR Afeditab® CR Nifedical® XL Nifeditab® CR Procardia Procardia®
+

Micafungin

No brand names on record
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
Updated Aug 8, 2026
Editorial policy · Data sources
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Interaction severity
Major
Potentially serious — often needs a change or close monitoring.
How we grade severity & evidence

Severity levels

  • Contraindicated: These should generally not be used together.
  • Major: Potentially serious — often needs a change or close monitoring.
  • Moderate: Can be significant — usually manageable with monitoring.
  • Minor: Usually limited clinical impact.

Evidence grades

  • Established: Well documented — supported by controlled studies or strong clinical data.
  • Probable: Good supporting evidence, though not definitively proven.
  • Suspected: Some evidence suggests this interaction, but it is not well established.
  • Possible: Limited or conflicting evidence; the interaction may occur.
  • Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Of 325 documented Nifedipine interactions, 266 are rated major — including this one.
Worried about symptoms right now? Contact your pharmacist or prescriber, or call Poison Control at 1-800-222-1222 (US). Call 911 for an emergency.
Onset
unspecified
Evidence
probable
Severity
Major

What happens

Increased NIFEdipine exposure

Interaction Deep Dive

In a clinical study, NIFEdipine AUC and Cmax were increased by 18% and 42% respectively, compared with NIFEdipine alone. Monitor patients receiving NIFEdipine and micafungin concomitantly for NIFEdipine toxicity and reduce the NIFEdipine dose if necessary12.

Why it happens (mechanism)

Unknown

Literature reports

1 report — tap to read

a) Plasma levels of NIFEdipine were increased in the presence of steady-state micafungin compared with NIFEdipine alone. NIFEdipine AUC and Cmax were increased by 18% and 42% respectively, compared with NIFEdipine alone 12.

Common questions

Can I take Nifedipine and Micafungin together?

Increased NIFEdipine exposure Always confirm with your pharmacist or prescriber before making any change.

How serious is the Nifedipine and Micafungin interaction?

It is rated major. Potentially serious — often needs a change or close monitoring.

How quickly could this interaction happen?

The documented onset is "unspecified". The timing of this interaction is not well characterized.

How strong is the evidence for this interaction?

The evidence is graded "probable". Good supporting evidence, though not definitively proven.

Questions for your pharmacist

  • Does my dose of Nifedipine or Micafungin need adjusting while I take them together?
  • What symptoms should prompt me to call you or my prescriber right away?
  • Does the timing of my doses matter for this combination?
  • Is there a safer alternative to one of these medications for me?

References (2)

  1. Product Information: MYCAMINE(R) intravenous injection, micafungin sodium intravenous injection. Astellas Pharma US Inc (per FDA), Northbrook, IL, 2019. DailyMed
  2. Product Information: MICAFUNGIN IN SODIUM CHLORIDE intravenous injection, micafungin sodium intravenous injection. Baxter Healthcare Corporation (per FDA), Deerfield, IL, 2023. DailyMed
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Nifedipine

Keep reading about Nifedipine

All Nifedipine interactions (325) Nifedipine drug information
Also serious with: Rifabutin Primidone Rifapentine Rifampin
Micafungin

Keep reading about Micafungin

All Micafungin interactions (5)
Also serious with: Azathioprine Mercaptopurine Methotrexate Methotrexate Injection
Beyond drug–drug

These medications also interact with supplements

Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:

Nifedipine + Activated Charcoal American Hellebore American Mistletoe Beer Coca Coleus Grapefruit Siberian Cocklebur + 265 more
Micafungin + Activated Charcoal Coffee Charcoal European Mandrake Glucomannan Guar Gum Gum Arabic Slippery Elm Tragacanth + 12 more

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This information is for education, not a substitute for professional medical advice. Do not start, stop, or change any medication without talking to your pharmacist or prescriber.