Nimesulide
91 interactions 5 explained in plain English
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
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Ketorolac Nasal Spray
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Ketorolac Ophthalmic
Ketorolac
Pemetrexed Injection
Epoprostenol
Major
Nimesulide Amitriptyline Elavil Explained An increased risk of bleeding Details Nimesulide Sertraline Explained An increased risk of bleeding Details Nimesulide Apixaban Eliquis Explained An increased risk of bleeding Details Nimesulide Aspirin Acuprin® An increased risk of bleeding, decreased renal function, and an increased risk of gastrointestinal adverse events Details Nimesulide Aspirin Rectal Aspirin An increased risk of bleeding, decreased renal function, and an increased risk of gastrointestinal adverse events Details Nimesulide Betrixaban Bevyxxa® An increased risk of bleeding Details Nimesulide Anagrelide Agrylin An increased risk of bleeding Details Nimesulide Bromfenac Ophthalmic Bromday® Increased risk of bleeding Details Nimesulide Budesonide Entocort Increased risk of gastrointestinal ulcer or bleeding Details Nimesulide Budesonide Nasal Spray Rhinocort Increased risk of gastrointestinal ulcer or bleeding Details Nimesulide Budesonide Oral Inhalation Pulmicort Increased risk of gastrointestinal ulcer or bleeding Details Nimesulide Clopidogrel Plavix An increased risk of bleeding Details Nimesulide Cyclosporine Injection Atopica An increased risk of cycloSPORINE nephrotoxicity Details Nimesulide Cyclosporine Ophthalmic Cequa An increased risk of cycloSPORINE nephrotoxicity Details Nimesulide Dabigatran Pradaxa® An increased risk of bleeding Details Nimesulide Dabigatran Etexilate An increased risk of bleeding Details Nimesulide Dalteparin Injection Fragmin An increased risk of bleeding Details Nimesulide Deflazacort Emflaza Increased risk of gastrointestinal ulcer or bleeding Details Nimesulide Dexamethasone Injection Decadron Increased risk of gastrointestinal ulcer or bleeding Details Nimesulide Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Increased risk of gastrointestinal ulcer or bleeding Details Nimesulide Diclofenac Ophthalmic Voltaren® Eye Drops Increased risk of bleeding Details Nimesulide Diclofenac Topical (Actinic Keratosis) Pennsaid Increased risk of bleeding Details Nimesulide Diclofenac Topical (Arthritis Pain) Pennsaid® Increased risk of bleeding Details Nimesulide Diclofenac Transdermal Patch Flector Increased risk of bleeding Details Nimesulide Digoxin Cardoxin® Increased digoxin exposure and prolonged half-life of digoxin Details Nimesulide Dipyridamole Permole® An increased risk of bleeding Details Nimesulide Edoxaban Savaysa An increased risk of bleeding Details Nimesulide Emtricitabine Emtriva Increased emtricitabine exposure and an increased risk of emtricitabine-related adverse effects Details Nimesulide Enoxaparin Lovenox An increased risk of bleeding Details Nimesulide Enoxaparin Injection Lovenox An increased risk of bleeding Details Nimesulide Epoprostenol Flolan An increased risk of bleeding Details Nimesulide Etodolac Lodine Increased risk of bleeding Details Nimesulide Fenoprofen Fenopron Increased risk of bleeding Details Nimesulide Flurbiprofen Ansaid Increased risk of bleeding Details Nimesulide Flurbiprofen Ophthalmic Ocufen Increased risk of bleeding Details Nimesulide Fondaparinux Arixtra An increased risk of bleeding Details Nimesulide Fondaparinux Injection Arixtra An increased risk of bleeding Details Nimesulide Furosemide Injection Disal Reduced diuretic effectiveness and possible nephrotoxicity Details Nimesulide Heparin An increased risk of bleeding Details Nimesulide Heparin Injection Lipo-Hepin® An increased risk of bleeding DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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