Nimesulide

91 interactions 5 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Nasal Spray Ketorolac Injection Ketorolac Ophthalmic Ketorolac Pemetrexed Injection Epoprostenol
4 Contraindicated 59 Major 28 Moderate
All (91) Contraindicated (4) Major (59) Moderate (28)

Major

Nimesulide Hydrocortisone Ala-Cort Increased risk of gastrointestinal ulcer or bleeding Details Nimesulide Hydrocortisone Injection A-Hydrocort® Increased risk of gastrointestinal ulcer or bleeding Details Nimesulide Ibuprofen Addaprin An increased risk of gastrointestinal toxicity Details Nimesulide Iloprost Aurlumyn An increased risk of bleeding Details Nimesulide Ketoprofen Actron® Increased risk of bleeding Details Nimesulide Lithium Carbonate Lithobid Increased lithium exposure and an increased risk of lithium toxicity Details Nimesulide Meclofenamate Meclodium® Increased risk of bleeding Details Nimesulide Mefenamic Acid Ponstel® Increased risk of bleeding Details Nimesulide Meloxicam Alloxate An increased risk of gastrointestinal toxicity and an increased risk of bleeding Details Nimesulide Meloxicam Injection Alloxate An increased risk of gastrointestinal toxicity and an increased risk of bleeding Details Nimesulide Melphalan Alkeran An increased risk of bleeding Details Nimesulide Melphalan Injection Alkeran An increased risk of bleeding Details Nimesulide Mesalamine Apriso Increased risk of bleeding Details Nimesulide Mesalamine Rectal Canasa Increased risk of bleeding Details Nimesulide Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Nimesulide Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Nimesulide Nabumetone Relafen Increased risk of bleeding Details Nimesulide Naproxen Aleve Increased risk of bleeding Details Nimesulide Pemetrexed Injection Alimta Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.