Drug Interaction Report

Pitavastatin and Cyclosporine Ophthalmic: Interaction Details

A pharmacist-reviewed analysis of the Pitavastatin and Cyclosporine Ophthalmic interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Cyclosporine Ophthalmic

Cequa Cequa® Restasis® Vevye
+

Pitavastatin

Livalo Livalo® Nikita Zypitamag Zypitamag®
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
Updated Aug 8, 2026
Editorial policy · Data sources
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Interaction severity
Contraindicated
These should generally not be used together.
How we grade severity & evidence

Severity levels

  • Contraindicated: These should generally not be used together.
  • Major: Potentially serious — often needs a change or close monitoring.
  • Moderate: Can be significant — usually manageable with monitoring.
  • Minor: Usually limited clinical impact.

Evidence grades

  • Established: Well documented — supported by controlled studies or strong clinical data.
  • Probable: Good supporting evidence, though not definitively proven.
  • Suspected: Some evidence suggests this interaction, but it is not well established.
  • Possible: Limited or conflicting evidence; the interaction may occur.
  • Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Of 19 documented Pitavastatin interactions, 2 are rated contraindicated — including this one.
Worried about symptoms right now? Contact your pharmacist or prescriber, or call Poison Control at 1-800-222-1222 (US). Call 911 for an emergency.
Onset
unspecified
Evidence
probable
Severity
Contraindicated

What happens

Increased pitavastatin exposure and increased risk of myopathy and rhabdomyolysis

Interaction Deep Dive

Concomitant use of cycloSPORINE and pitavastatin is contraindicated. Coadministration significantly increases pitavastatin exposure and increases the risk of myopathy and rhabdomyolysis1.

Why it happens (mechanism)

Unknown

Literature reports

1 report — tap to read

a) Coadministration of cycloSPORINE 2 mg/kg on day 6 with pitavastatin 2 mg daily for 6 days has resulted in 4.6- and 6.6-fold increases in lovastatin AUC and Cmax 2.

Common questions

Can I take Pitavastatin and Cyclosporine Ophthalmic together?

Increased pitavastatin exposure and increased risk of myopathy and rhabdomyolysis Always confirm with your pharmacist or prescriber before making any change.

How serious is the Pitavastatin and Cyclosporine Ophthalmic interaction?

It is rated contraindicated. These should generally not be used together.

How quickly could this interaction happen?

The documented onset is "unspecified". The timing of this interaction is not well characterized.

How strong is the evidence for this interaction?

The evidence is graded "probable". Good supporting evidence, though not definitively proven.

Questions for your pharmacist

  • Does my dose of Pitavastatin or Cyclosporine Ophthalmic need adjusting while I take them together?
  • What symptoms should prompt me to call you or my prescriber right away?
  • Does the timing of my doses matter for this combination?
  • Is there a safer alternative to one of these medications for me?

References (2)

  1. Product Information: LIVALO(R) oral tablets, pitavastatin oral tablets. Kowa Pharmaceuticals America Inc (per FDA), Montgomery, AL, 2019. DailyMed
  2. Product Information: ZYPITAMAG oral tablets, pitavastatin oral tablets. Zydus Pharmaceuticals (USA) Inc. (per FDA), Pennington, NJ, 2017. DailyMed
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Cyclosporine Ophthalmic

Keep reading about Cyclosporine Ophthalmic

All Cyclosporine Ophthalmic interactions (545) Cyclosporine Ophthalmic drug information
Also serious with: Dronedarone Elagolix Ensitrelvir Ezetimibe
Pitavastatin

Keep reading about Pitavastatin

All Pitavastatin interactions (19) Pitavastatin drug information
Also serious with: Cyclosporine Injection Fluorouracil Injection Niacin Leniolisib
Beyond drug–drug

These medications also interact with supplements

Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:

Pitavastatin + Activated Charcoal Beer Grapefruit Siberian Cocklebur Wine Adrafinil African Wild Potato Ashwagandha + 118 more

major · moderate · minor — check everything you take with our drug–supplement interaction checker.

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This information is for education, not a substitute for professional medical advice. Do not start, stop, or change any medication without talking to your pharmacist or prescriber.