Primidone

Name: Primidone Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

204 interactions 13 explained in plain English

Also sold as: Mysoline

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Doravirine Nifedipine Maraviroc Alfuzosin Nintedanib Felbamate

3 Contraindicated 190 Major 10 Moderate 1 Minor

All (204) Contraindicated (3) Major (190) Moderate (10) Minor (1)

Moderate

Primidone Leucovorin Injection Vykoura Reduced efficacy PHENobarbital or primidone (prodrug of PHENobarbital) and an increased risk or frequency of seizures Details Primidone Levothyroxine Ermeza Reduced levothyroxine exposure and reduced efficacy of levothyroxine Details Primidone Ospemifene Osphena Decreased ospemifene exposure and efficacy Details

Minor

Primidone Nimodipine Nimotop Decreased nimodipine effectiveness Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.