Protein C

46 interactions 2 explained in plain English

Also sold as: Ceprotin

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Defibrotide Injection Etodolac Orlistat Edoxaban Epoprostenol Nintedanib

1 Contraindicated 44 Major 1 Moderate

All (46) Contraindicated (1) Major (44) Moderate (1)

Contraindicated

Protein C Defibrotide Injection Defitelio Increased risk of bleeding Details

Major

Protein C Sertraline Explained An increased risk of bleeding Details Protein C Apixaban Eliquis Explained An increased risk of bleeding and can cause serious, potentially fatal bleeding Details Protein C Aspirin Acuprin® Increased risk of bleeding Details Protein C Aspirin Rectal Aspirin Increased risk of bleeding Details Protein C Betrixaban Bevyxxa® Increased risk of bleeding Details Protein C Anagrelide Agrylin Increased risk of bleeding Details Protein C Bromfenac Ophthalmic Bromday® An increased risk of bleeding Details Protein C Caplacizumab-Yhdp Injection Cablivi An increased risk of bleeding Details Protein C Clopidogrel Plavix Increased risk of bleeding Details Protein C Dabigatran Pradaxa® An increased risk of bleeding Details Protein C Dabigatran Etexilate An increased risk of bleeding Details Protein C Diclofenac Ophthalmic Voltaren® Eye Drops An increased risk of bleeding Details Protein C Diclofenac Topical (Actinic Keratosis) Pennsaid An increased risk of bleeding Details Protein C Diclofenac Topical (Arthritis Pain) Pennsaid® An increased risk of bleeding Details Protein C Diclofenac Transdermal Patch Flector An increased risk of bleeding Details Protein C Dipyridamole Permole® Increased risk of bleeding Details Protein C Doxycycline Injection Acticlate An increased risk of bleeding Details Protein C Edoxaban Savaysa Increased risk of bleeding Details Protein C Epoprostenol Flolan Increased risk of bleeding Details Protein C Etodolac Lodine An increased risk of bleeding Details Protein C Fenoprofen Fenopron An increased risk of bleeding Details Protein C Flurbiprofen Ansaid An increased risk of bleeding Details Protein C Flurbiprofen Ophthalmic Ocufen An increased risk of bleeding Details Protein C Ibrutinib Imbruvica Increased risk of bleeding Details Protein C Ibuprofen Addaprin An increased risk of bleeding Details Protein C Iloprost Aurlumyn Increased risk of bleeding Details Protein C Ketoprofen Actron® An increased risk of bleeding Details Protein C Ketorolac Acular An increased risk of bleeding Details Protein C Ketorolac Injection Acular An increased risk of bleeding Details Protein C Ketorolac Nasal Spray Sprix An increased risk of bleeding Details Protein C Ketorolac Ophthalmic Acular An increased risk of bleeding Details Protein C Lecanemab-Irmb Injection Leqembi An increased risk of amyloid related imaging abnormalities (ARIA), or intracerebral hemorrhage Details Protein C Meclofenamate Meclodium® An increased risk of bleeding Details Protein C Mefenamic Acid Ponstel® An increased risk of bleeding Details Protein C Meloxicam Alloxate An increased risk of bleeding Details Protein C Meloxicam Injection Alloxate An increased risk of bleeding Details Protein C Minocycline Amzeeq An increased risk of bleeding Details Protein C Minocycline Topical Amzeeq An increased risk of bleeding Details Protein C Nabumetone Relafen An increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.