Relacorilant and Colchicine: Interaction Details
AI-assisted, pharmacist-reviewed · AI content regenerated Jul 11, 2026 · Source data updated Jul 2, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Relacorilant
Colchicine
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
Relacorilant can make colchicine build up in your body. Colchicine (used for gout and to prevent flares) is normally broken down by a liver enzyme called CYP3A4. Relacorilant slows that enzyme down, so colchicine can clear more slowly and rise to higher levels than expected.
That matters because colchicine is a drug where small changes can cause big problems, like severe diarrhea, stomach upset, muscle pain or weakness, and other serious effects. The good news: your care team knows how to handle this. Do not stop or change either medicine on your own, but do talk with your pharmacist or doctor so they can decide the safest plan for you.
Effect: Relacorilant inhibits CYP3A4, reducing colchicine metabolism and increasing colchicine exposure (AUC/Cmax) with a higher risk of dose-related toxicity.
- Mechanism: CYP3A4 inhibition; colchicine is a CYP3A4 (and P-gp) substrate. Neither agent is activated by this pathway, so effect is increased colchicine exposure.
- Direction: increased colchicine effect/toxicity (GI, myotoxicity, neuromuscular, marrow suppression).
- Onset: unspecified. Evidence: probable. Severity: major.
- Management: Avoid concomitant use unless otherwise recommended. If unavoidable, dose may need individualized reduction and closer clinical monitoring; use special caution in renal or hepatic impairment.
What happens
Increased CYP3A4 substrate exposure and an increased risk of CYP3A4-substrate-related adverse reactions
Interaction Deep Dive
Unless there is specific guidance to do otherwise, relacorilant should not be given together with CYP3A4 substrates. Taking them together can raise the exposure to these substrates and heighten the likelihood of adverse reactions associated with them1.
Why it happens (mechanism)
Inhibition of CYP3A4-mediated metabolism of relacorilant
How to manage this interaction
Keep taking both medicines as prescribed and let your prescriber and pharmacist know you are on this combination so they can review it.
- The guidance on file is to avoid using them together unless your care team specifically recommends it.
- If they do keep you on both, your colchicine dose may need to be adjusted and individualized, and your team may monitor you more closely.
- Report early warning signs promptly: persistent diarrhea, nausea/vomiting, unexplained muscle pain or weakness, numbness/tingling, or unusual fatigue.
- Remind your team of any kidney or liver problems, since these raise the risk.
Management is individual — confirm any change with your pharmacist or prescriber.
Literature reports
1 report — tap to read
a) In drug interaction studies, giving relacorilant 350 mg once daily in the fasted state (1.8 times the relacorilant exposure achieved at the recommended dose) for 10 days together with midazolam (a CYP3A4 substrate) raised the Cmax by 3.1-fold and the AUC by 8.9-fold 1.
Common questions
Can I take Relacorilant and Colchicine together?
Relacorilant can raise colchicine levels and its toxicity risk, so this combination is generally avoided; do not change anything on your own, but check with your pharmacist or doctor about the safest plan. Always confirm with your pharmacist or prescriber before making any change.
How serious is the Relacorilant and Colchicine interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How is the Relacorilant and Colchicine interaction managed?
Keep taking both medicines as prescribed and let your prescriber and pharmacist know you are on this combination so they can review it. The guidance on file is to avoid using them together unless your care team specifically recommends it. If they do keep you on both, your colchicine dose may need to be adjusted and individualized, and your team may monitor you more closely. Report early warning si… Management is individual — always follow your own care team's guidance.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
Questions for your pharmacist
- Does my dose of Relacorilant or Colchicine need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: LIFYORLI™ oral capsules, relacorilant oral capsules. Corcept Therapeutics Incorporated (Per Manufacturer), Redwood City, CA, 2026. DailyMed
Keep reading about Relacorilant
Keep reading about Colchicine
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