Repotrectinib

Major

Repotrectinib Estradiol Topical Divigel Reduced hormonal contraceptive exposure, reduced effectiveness of hormonal contraceptive and an increased risk of breakthrough ble... Details Repotrectinib Estradiol Transdermal Patch Alora® Reduced hormonal contraceptive exposure, reduced effectiveness of hormonal contraceptive and an increased risk of breakthrough ble... Details Repotrectinib Everolimus Afinitor Reduced CYP3A4 substrates exposure and reduced efficacy of CYP3A4 substrates Details Repotrectinib Felodipine Plendil® Increased repotrectinib exposure and an increased risk of repotrectinib-related adverse effects Details Repotrectinib Fentanyl Transdermal Patch Duragesic® Reduced CYP3A4 substrates exposure and reduced efficacy of CYP3A4 substrates Details Repotrectinib Finerenone Kerendia Reduced finerenone exposure and reduced efficacy of finerenone Details Repotrectinib Fostamatinib Tavalisse Increased repotrectinib exposure and an increased risk of repotrectinib-related adverse effects Details Repotrectinib Ibrexafungerp Brexafemme Increased repotrectinib exposure and an increased risk of repotrectinib-related adverse effects Details Repotrectinib Istradefylline Nourianz Increased repotrectinib exposure and an increased risk of repotrectinib-related adverse effects Details Repotrectinib Ketoconazole Topical Extina® Foam Increased repotrectinib exposure and an increased risk of repotrectinib-related adverse effects Details Repotrectinib Lenacapavir Injection Sunlenca Reduced lenacapavir exposure which may result in the loss of therapeutic effect and development of resistance to lenacapavir, incr... Details Repotrectinib Lenacapavir Oral Sunlenca Reduced lenacapavir exposure which may result in the loss of therapeutic effect and development of resistance to lenacapavir, incr... Details Repotrectinib Leniolisib Joenja Reduced leniolisib exposure and reduced efficacy of leniolisib Details Repotrectinib Letermovir Injection Prevymis Increased repotrectinib exposure and an increased risk of repotrectinib-related adverse effects Details Repotrectinib Levonorgestrel After banger Reduced levonorgestrel exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Repotrectinib Levonorgestrel Intrauterine System Kyleena Reduced levonorgestrel exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Repotrectinib Lumateperone Caplyta Reduced lumateperone exposure Details Repotrectinib Lurasidone Latuda Reduced lurasidone exposure Details Repotrectinib Medroxyprogesterone Amen® Reduced hormonal contraceptive exposure, reduced effectiveness of hormonal contraceptive and an increased risk of breakthrough ble... Details Repotrectinib Medroxyprogesterone Injection Depo-Provera Reduced hormonal contraceptive exposure, reduced effectiveness of hormonal contraceptive and an increased risk of breakthrough ble... Details Repotrectinib Midostaurin Rydapt Reduced CYP3A4 substrates exposure and reduced efficacy of CYP3A4 substrates Details Repotrectinib Mitapivat Aqvesme Reduced repotrectinib exposure, reduced mitapivat exposure and reduced efficacy of mitapivat Details Repotrectinib Nafcillin Injection Unipen® Injection Reduced repotrectinib exposure and reduced efficacy of repotrectinib Details Repotrectinib Neratinib Nerlynx Increased repotrectinib exposure, an increased risk of repotrectinib-related adverse effects, reduced CYP3A4 substrates exposure a... Details Repotrectinib Nifedipine Adalat® Increased repotrectinib exposure, an increased risk of repotrectinib-related adverse effects and reduced NIFEdipine exposure Details Repotrectinib Olaparib Lynparza Reduced CYP3A4 substrates exposure and reduced efficacy of CYP3A4 substrates Details