Revumenib and Nafcillin Injection: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Nafcillin Injection
Revumenib
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Reduced revumenib exposure and reduced efficacy of revumenib or an increased risk of QT prolongation associated with the M1 metabolite
Interaction Deep Dive
Avoid the concomitant use of revumenib with a moderate or strong CYP3A4 inducer, as it may reduce revumenib and increase M1 systemic exposure, which may reduce revumenib efficacy or increase the risk of QT prolongation associated with the M1 metabolite1.
Why it happens (mechanism)
Induction of CYP3A4-mediated metabolism of revumenib
Literature reports
1 report — tap to read
a) Revumenib exposure is expected to decrease and M1 exposure is expected to increase with strong and moderate CYP3A4 inducers 1.
Common questions
Can I take Revumenib and Nafcillin Injection together?
Reduced revumenib exposure and reduced efficacy of revumenib or an increased risk of QT prolongation associated with the M1 metabolite Always confirm with your pharmacist or prescriber before making any change.
How serious is the Revumenib and Nafcillin Injection interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Revumenib or Nafcillin Injection need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: REVUFORJ oral tablets, revumenib oral tablets. Syndax Pharmaceuticals, Inc. (per FDA), Waltham, MA, 2024. DailyMed
Keep reading about Nafcillin Injection
Keep reading about Revumenib
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