Ritlecitinib

Name: Ritlecitinib Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

51 interactions 5 explained in plain English

Also sold as: Litfulo

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Dofetilide Cyclosporine Ophthalmic Nisoldipine Abemaciclib Cyclosporine Injection Doxorubicin

48 Major 3 Moderate

All (51) Major (48) Moderate (3)

Major

Ritlecitinib Methylergonovine Methergine Increased methylergonovine exposure and an increased risk of vasospasm, cerebral ischemia and/or ischemia of extremities Details Ritlecitinib Midazolam Nasal Spray Nayzilam Increased CYP3A substrate exposure and an increased risk of CYP3A substrate-related adverse reactions Details Ritlecitinib Midazolam Injection Nayzilam Increased CYP3A substrate exposure and an increased risk of CYP3A substrate-related adverse reactions Details Ritlecitinib Midostaurin Rydapt Increased CYP3A substrate exposure and an increased risk of CYP3A substrate-related adverse reactions Details Ritlecitinib Mitapivat Aqvesme Increased mitapivat exposure Details Ritlecitinib Naloxegol Movantik Increased CYP3A substrate exposure and an increased risk of CYP3A substrate-related adverse reactions Details Ritlecitinib Nifedipine Adalat® Increased NIFEdipine exposure Details Ritlecitinib Nisoldipine Sular Increased CYP3A substrate exposure and an increased risk of CYP3A substrate-related adverse reactions Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.