Rofecoxib

92 interactions 5 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Ketorolac Injection Ketorolac Nasal Spray Ketorolac Ophthalmic Pemetrexed Injection Aspirin
4 Contraindicated 60 Major 28 Moderate
All (92) Contraindicated (4) Major (60) Moderate (28)

Major

Rofecoxib Heparin Injection Lipo-Hepin® An increased risk of bleeding Details Rofecoxib Hydrocortisone Ala-Cort Increased risk of gastrointestinal ulcer or bleeding Details Rofecoxib Hydrocortisone Injection A-Hydrocort® Increased risk of gastrointestinal ulcer or bleeding Details Rofecoxib Ibuprofen Addaprin An increased risk of gastrointestinal toxicity Details Rofecoxib Iloprost Aurlumyn An increased risk of bleeding Details Rofecoxib Ketoprofen Actron® Increased risk of bleeding Details Rofecoxib Lithium Carbonate Lithobid Increased lithium exposure and an increased risk of lithium toxicity Details Rofecoxib Meclofenamate Meclodium® Increased risk of bleeding Details Rofecoxib Mefenamic Acid Ponstel® Increased risk of bleeding Details Rofecoxib Meloxicam Alloxate An increased risk of gastrointestinal toxicity and an increased risk of bleeding Details Rofecoxib Meloxicam Injection Alloxate An increased risk of gastrointestinal toxicity and an increased risk of bleeding Details Rofecoxib Melphalan Alkeran An increased risk of bleeding Details Rofecoxib Melphalan Injection Alkeran An increased risk of bleeding Details Rofecoxib Mesalamine Apriso Increased risk of bleeding Details Rofecoxib Mesalamine Rectal Canasa Increased risk of bleeding Details Rofecoxib Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Rofecoxib Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Rofecoxib Nabumetone Relafen Increased risk of bleeding Details Rofecoxib Naproxen Aleve Increased risk of bleeding Details Rofecoxib Pemetrexed Injection Alimta Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.