Sparsentan and Aficamten: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Sparsentan
Aficamten
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Reduced CYP2C19/CYP2C9 substrate exposure and reduced efficacy of CYP2C19/CYP2C9 substrate
Interaction Deep Dive
Concomitant administration of sparsentan (inducer of CYP2C9 and CYP2C19) with drugs that are both CYP2C9 and CYP2C19 substrates may reduce these substrates exposure, which may reduce the efficacy of these substrates. Monitor for efficacy of these substrates and consider dosage adjustment as required1.
Why it happens (mechanism)
Induction of CYP2C9-substrate metabolism by sparsentan; induction of CYP2C19-substrate metabolism by sparsentan
Common questions
Can I take Sparsentan and Aficamten together?
Reduced CYP2C19/CYP2C9 substrate exposure and reduced efficacy of CYP2C19/CYP2C9 substrate Always confirm with your pharmacist or prescriber before making any change.
How serious is the Sparsentan and Aficamten interaction?
It is rated moderate. Can be significant — usually manageable with monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Sparsentan or Aficamten need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (1)
- Product Information: FILSPARI® oral tablets, sparsentan oral tablets. Travere Therapeutics Inc, San Diego, CA, 2026. DailyMed
Keep reading about Sparsentan
Keep reading about Aficamten
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Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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