Tamoxifen

Name: Tamoxifen Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

89 interactions 5 explained in plain English

Also sold as: Nolvadex® Soltamox Soltamox®

About Tamoxifen

Tamoxifen is an antiestrogen medication used to treat breast cancer and reduce the risk of developing it in high-risk women. Read the full Tamoxifen drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketoconazole Topical Lefamulin Oxaliplatin Injection Dasatinib Sertraline Ofloxacin

2 Contraindicated 81 Major 6 Moderate

All (89) Contraindicated (2) Major (81) Moderate (6)

Major

Tamoxifen Ofloxacin Otic Floxin® Otic An increased risk of QT interval prolongation Details Tamoxifen Olodaterol Oral Inhalation Striverdi An increased risk of QT interval prolongation and an increased risk of ventricular arrhythmias Details Tamoxifen Oxaliplatin Injection Eloxatin® Increased risk of QT-interval prolongation Details

Moderate

Tamoxifen Aldesleukin Proleukin An increased risk for hypersensitivity reactions (erythema, pruritus, hypotension) Details Tamoxifen Diphenhydramine Injection Banophen Decreased plasma concentrations of the active metabolites of tamoxifen Details Tamoxifen Diphenhydramine Topical Afterbite with Antihistamine Decreased plasma concentrations of the active metabolites of tamoxifen Details Tamoxifen Levothyroxine Ermeza Decreased levothyroxine exposure Details Tamoxifen Medroxyprogesterone Amen® Reduced N-desmethyl tamoxifen exposure Details Tamoxifen Medroxyprogesterone Injection Depo-Provera Reduced N-desmethyl tamoxifen exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.