Tenoxicam

96 interactions 5 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Ophthalmic Ketorolac Ketorolac Nasal Spray Ketorolac Injection Melphalan Injection Fondaparinux
4 Contraindicated 63 Major 28 Moderate 1 Minor
All (96) Contraindicated (4) Major (63) Moderate (28) Minor (1)

Major

Tenoxicam Fondaparinux Injection Arixtra An increased risk of bleeding Details Tenoxicam Furosemide Injection Disal Reduced diuretic effectiveness and possible nephrotoxicity Details Tenoxicam Heparin An increased risk of bleeding Details Tenoxicam Heparin Injection Lipo-Hepin® An increased risk of bleeding Details Tenoxicam Hydrocortisone Ala-Cort Increased risk of gastrointestinal ulcer or bleeding Details Tenoxicam Hydrocortisone Injection A-Hydrocort® Increased risk of gastrointestinal ulcer or bleeding Details Tenoxicam Ibuprofen Addaprin An increased risk of gastrointestinal toxicity Details Tenoxicam Iloprost Aurlumyn An increased risk of bleeding Details Tenoxicam Ketoprofen Actron® Increased risk of bleeding Details Tenoxicam Lithium Carbonate Lithobid Increased lithium exposure and an increased risk of lithium toxicity Details Tenoxicam Meclofenamate Meclodium® Increased risk of bleeding Details Tenoxicam Mefenamic Acid Ponstel® Increased risk of bleeding Details Tenoxicam Meloxicam Alloxate An increased risk of gastrointestinal toxicity and an increased risk of bleeding Details Tenoxicam Meloxicam Injection Alloxate An increased risk of gastrointestinal toxicity and an increased risk of bleeding Details Tenoxicam Melphalan Alkeran An increased risk of bleeding Details Tenoxicam Melphalan Injection Alkeran An increased risk of bleeding Details Tenoxicam Mesalamine Apriso Increased risk of bleeding Details Tenoxicam Mesalamine Rectal Canasa Increased risk of bleeding Details Tenoxicam Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Tenoxicam Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Tenoxicam Nabumetone Relafen Increased risk of bleeding Details Tenoxicam Naproxen Aleve Increased risk of bleeding Details Tenoxicam Pemetrexed Injection Alimta Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.