Drug Interaction Report

Toloxatone and Levodopa Oral Inhalation: Interaction Details

Name: Toloxatone and Levodopa Oral Inhalation Interaction
Creator: Dr. Brian Staiger, PharmD, BCPS

A pharmacist-reviewed analysis of the Toloxatone and Levodopa Oral Inhalation interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Levodopa Oral Inhalation

Inbrija Inbrija®

Toloxatone

No brand names on record

Medically reviewed by

Dr. Brian Staiger, PharmD, BCPS

Updated Aug 8, 2026

Editorial policy · Data sources

Interaction severity

Contraindicated

These should generally not be used together.

Minor

Moderate

Major

Contraindicated

How we grade severity & evidence

Severity levels

Contraindicated: These should generally not be used together.
Major: Potentially serious — often needs a change or close monitoring.
Moderate: Can be significant — usually manageable with monitoring.
Minor: Usually limited clinical impact.

Evidence grades

Established: Well documented — supported by controlled studies or strong clinical data.
Probable: Good supporting evidence, though not definitively proven.
Suspected: Some evidence suggests this interaction, but it is not well established.
Possible: Limited or conflicting evidence; the interaction may occur.
Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Worried about symptoms right now? Contact your pharmacist or prescriber, or call Poison Control at 1-800-222-1222 (US). Call 911 for an emergency.

Onset

rapid

Evidence

probable

Severity

Contraindicated

What happens

Hypertension

Interaction Deep Dive

Concurrent administration of levodopa with MAOIs has resulted in hypertensive reactions²³¹ and therefore is contraindicated ⁴.

Why it happens (mechanism)

Increased dopamine and/or norepinephrine availability

Common questions

Can I take Toloxatone and Levodopa Oral Inhalation together?

Hypertension Always confirm with your pharmacist or prescriber before making any change.

How serious is the Toloxatone and Levodopa Oral Inhalation interaction?

It is rated contraindicated. These should generally not be used together.

How quickly could this interaction happen?

The documented onset is "rapid". Effects can appear quickly, often within about 24 hours of combining the drugs.

How strong is the evidence for this interaction?

The evidence is graded "probable". Good supporting evidence, though not definitively proven.

Questions for your pharmacist

Does my dose of Toloxatone or Levodopa Oral Inhalation need adjusting while I take them together?
What symptoms should prompt me to call you or my prescriber right away?
Does the timing of my doses matter for this combination?
Is there a safer alternative to one of these medications for me?

References (4)

Hodge JV: Use of monoamine-oxidase inhibitors. Lancet 1965; 1:764. DOI
Teychenne PF, Calne DB, Lewis PJ, et al: Interactions of levodopa with inhibitors of monoamine oxidase and l-aromatic amino acid decarboxylase. Clin Pharmacol Ther 1975; 18:273-277. PubMed
Hunter KR, Boakes AJ, Laurence DR, et al: Monoamine oxidase inhibitors and L-dopa. Br Med J 1970; 3:388. PubMed
Product Information: Larodopa(R), levodopa. Roche Laboratories Inc. Nutley, NJ, 1997. DailyMed

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HelloPharmacist doesn't license one of the big commercial interaction databases, so what you'll find here is not a complete list of every known drug interaction. Instead, each entry is researched, analyzed, and written up individually — documented from the published literature, reviewed by a pharmacist, and cited so you can check every source yourself.

If a combination isn't listed here, it means we haven't documented it yet — never that it's safe. For screening a full medication list, we recommend pairing this site with a comprehensive tool like the Drugs.com Interaction Checker and, most importantly, a review by your own pharmacist. For a deep, plain-English, fully sourced explanation of a specific documented interaction — that's exactly what we built this for.

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