Treprostinil

54 interactions 3 explained in plain English
Also sold as: Orenitram Orenitram® Remodulin Tyvaso Yutrepia
About Treprostinil

Treprostinil is used to treat certain kinds of pulmonary arterial hypertension (PAH; high blood pressure in the vessels carrying blood to the lungs, causing shortness of breath, dizziness, and tiredness). Treprostinil may improve the ability to exercise and slow the worsening of symptoms in patients with PAH. Treprosti… Read the full Treprostinil drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Abrocitinib Defibrotide Injection Melphalan Injection Apixaban Naproxen Fondaparinux
2 Contraindicated 43 Major 9 Moderate
All (54) Contraindicated (2) Major (43) Moderate (9)

Major

Treprostinil Sertraline Explained An increased risk of bleeding Details Treprostinil Apixaban Eliquis Explained Increased risk of bleeding and can cause serious, potentially fatal bleeding Details Treprostinil Aspirin Acuprin® An increased risk of bleeding Details Treprostinil Aspirin Rectal Aspirin An increased risk of bleeding Details Treprostinil Betrixaban Bevyxxa® Increased risk of bleeding Details Treprostinil Anagrelide Agrylin Increased bleeding risk Details Treprostinil Bromfenac Ophthalmic Bromday® An increased risk of bleeding Details Treprostinil Caplacizumab-Yhdp Injection Cablivi An increased risk of bleeding Details Treprostinil Clopidogrel Plavix An increased risk of bleeding Details Treprostinil Dabigatran Pradaxa® Increased risk of bleeding Details Treprostinil Dabigatran Etexilate Increased risk of bleeding Details Treprostinil Dalteparin Injection Fragmin Increased risk of bleeding Details Treprostinil Diclofenac Ophthalmic Voltaren® Eye Drops An increased risk of bleeding Details Treprostinil Diclofenac Topical (Actinic Keratosis) Pennsaid An increased risk of bleeding Details Treprostinil Diclofenac Topical (Arthritis Pain) Pennsaid® An increased risk of bleeding Details Treprostinil Diclofenac Transdermal Patch Flector An increased risk of bleeding Details Treprostinil Dipyridamole Permole® An increased risk of bleeding Details Treprostinil Edoxaban Savaysa Increased risk of bleeding Details Treprostinil Enoxaparin Lovenox Increased risk of bleeding Details Treprostinil Enoxaparin Injection Lovenox Increased risk of bleeding Details Treprostinil Etodolac Lodine An increased risk of bleeding Details Treprostinil Fenoprofen Fenopron An increased risk of bleeding Details Treprostinil Flurbiprofen Ansaid An increased risk of bleeding Details Treprostinil Flurbiprofen Ophthalmic Ocufen An increased risk of bleeding Details Treprostinil Fondaparinux Arixtra Increased risk of bleeding Details Treprostinil Fondaparinux Injection Arixtra Increased risk of bleeding Details Treprostinil Heparin Increased risk of bleeding Details Treprostinil Heparin Injection Lipo-Hepin® Increased risk of bleeding Details Treprostinil Ibrutinib Imbruvica Increased risk of bleeding Details Treprostinil Ibuprofen Addaprin An increased risk of bleeding Details Treprostinil Ketoprofen Actron® An increased risk of bleeding Details Treprostinil Ketorolac Acular An increased risk of bleeding Details Treprostinil Ketorolac Injection Acular An increased risk of bleeding Details Treprostinil Ketorolac Nasal Spray Sprix An increased risk of bleeding Details Treprostinil Ketorolac Ophthalmic Acular An increased risk of bleeding Details Treprostinil Meclofenamate Meclodium® An increased risk of bleeding Details Treprostinil Mefenamic Acid Ponstel® An increased risk of bleeding Details Treprostinil Meloxicam Alloxate An increased risk of bleeding Details Treprostinil Meloxicam Injection Alloxate An increased risk of bleeding Details Treprostinil Melphalan Alkeran An increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.