Treprostinil

Name: Treprostinil Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

54 interactions 3 explained in plain English

Also sold as: Orenitram Orenitram® Remodulin Tyvaso Yutrepia

About Treprostinil

Treprostinil is used to treat certain kinds of pulmonary arterial hypertension (PAH; high blood pressure in the vessels carrying blood to the lungs, causing shortness of breath, dizziness, and tiredness). Treprostinil may improve the ability to exercise and slow the worsening of symptoms in patients with PAH. Treprosti… Read the full Treprostinil drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Abrocitinib Defibrotide Injection Melphalan Injection Apixaban Naproxen Fondaparinux

2 Contraindicated 43 Major 9 Moderate

All (54) Contraindicated (2) Major (43) Moderate (9)

Major

Treprostinil Melphalan Injection Alkeran An increased risk of bleeding Details Treprostinil Nabumetone Relafen An increased risk of bleeding Details Treprostinil Naproxen Aleve An increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.