Trichlormethiazide

52 interactions 4 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Bromfenac Ophthalmic Flecainide Etodolac Arsenic Trioxide Hydromorphone Rectal Aspirin
36 Major 16 Moderate
All (52) Major (36) Moderate (16)

Major

Trichlormethiazide Acetaminophen And Codeine Capital® & Codeine Explained Reduced diuretic efficacy Details Trichlormethiazide Albuterol Oral Inhalation Accuneb® Explained An increased risk of ECG changes or hypokalemia Details Trichlormethiazide Buprenorphine Belbuca Explained Reduced efficacy of diuretics Details Trichlormethiazide Arsenic Trioxide Trisenox Increased risk of QT-interval prolongation and torsade de pointes Details Trichlormethiazide Arsenic Trioxide Injection Trisenox Increased risk of QT-interval prolongation and torsade de pointes Details Trichlormethiazide Aspirin Acuprin® Reduced diuretic effectiveness and possible nephrotoxicity Details Trichlormethiazide Aspirin Rectal Aspirin Reduced diuretic effectiveness and possible nephrotoxicity Details Trichlormethiazide Bromfenac Ophthalmic Bromday® Reduced diuretic effectiveness and possible nephrotoxicity Details Trichlormethiazide Cefepime Injection Maxipime® An increased risk of nephrotoxicity Details Trichlormethiazide Diclofenac Ophthalmic Voltaren® Eye Drops Reduced diuretic effectiveness and possible nephrotoxicity Details Trichlormethiazide Diclofenac Topical (Actinic Keratosis) Pennsaid Reduced diuretic effectiveness and possible nephrotoxicity Details Trichlormethiazide Diclofenac Topical (Arthritis Pain) Pennsaid® Reduced diuretic effectiveness and possible nephrotoxicity Details Trichlormethiazide Diclofenac Transdermal Patch Flector Reduced diuretic effectiveness and possible nephrotoxicity Details Trichlormethiazide Digoxin Cardoxin® Increased risk of digitalis toxicity (nausea, vomiting, arrhythmias) Details Trichlormethiazide Etodolac Lodine Reduced diuretic effectiveness and possible nephrotoxicity Details Trichlormethiazide Fenoprofen Fenopron Reduced diuretic effectiveness and possible nephrotoxicity Details Trichlormethiazide Fentanyl Transdermal Patch Duragesic® Reduced diuretic efficacy Details Trichlormethiazide Flecainide Tambocor® Increased risk of electrolyte imbalance and subsequent cardiotoxicity Details Trichlormethiazide Flurbiprofen Ansaid Reduced diuretic effectiveness and possible nephrotoxicity Details Trichlormethiazide Flurbiprofen Ophthalmic Ocufen Reduced diuretic effectiveness and possible nephrotoxicity Details Trichlormethiazide Hydromorphone Injection Dilaudid Reduced efficacy of diuretics Details Trichlormethiazide Hydromorphone Rectal available generically Reduced efficacy of diuretics Details Trichlormethiazide Ibuprofen Addaprin Reduced diuretic effectiveness and possible nephrotoxicity Details Trichlormethiazide Ketoprofen Actron® Reduced diuretic effectiveness and possible nephrotoxicity Details Trichlormethiazide Ketorolac Acular Reduced diuretic effectiveness and possible nephrotoxicity Details Trichlormethiazide Ketorolac Injection Acular Reduced diuretic effectiveness and possible nephrotoxicity Details Trichlormethiazide Ketorolac Nasal Spray Sprix Reduced diuretic effectiveness and possible nephrotoxicity Details Trichlormethiazide Ketorolac Ophthalmic Acular Reduced diuretic effectiveness and possible nephrotoxicity Details Trichlormethiazide Lithium Carbonate Lithobid Lithium toxicity Details Trichlormethiazide Meclofenamate Meclodium® Reduced diuretic effectiveness and possible nephrotoxicity Details Trichlormethiazide Mefenamic Acid Ponstel® Reduced diuretic effectiveness and possible nephrotoxicity Details Trichlormethiazide Meloxicam Alloxate Reduced diuretic effectiveness and possible nephrotoxicity Details Trichlormethiazide Meloxicam Injection Alloxate Reduced diuretic effectiveness and possible nephrotoxicity Details Trichlormethiazide Morphine Injection Astramorph® PF Reduced efficacy of diuretics Details Trichlormethiazide Nabumetone Relafen Reduced diuretic effectiveness and possible nephrotoxicity Details Trichlormethiazide Naproxen Aleve Reduced diuretic effectiveness and possible nephrotoxicity Details

Moderate

Trichlormethiazide Lisinopril Prinivil Explained Reduction of blood pressure Details Trichlormethiazide Asenapine Transdermal Patch Secuado An increased risk of hypotension Details Trichlormethiazide Benazepril Lotensin Reduction of blood pressure Details Trichlormethiazide Calcitriol Rocaltrol Increased serum calcium levels resulting in hypercalcemia Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.