Vimseltinib and Colchicine: Interaction Details
AI-assisted, pharmacist-reviewed · AI content regenerated Jul 11, 2026 · Source data updated Jul 2, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Colchicine
Vimseltinib
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
These two medicines can interact. Colchicine (Colcrys, Gloperba, Lodoco, Mitigare) is carried out of your body with the help of a transporter called P-gp. Vimseltinib (Romvimza) can slow that transporter down. When that happens, more colchicine can build up in your body, which can raise the risk of colchicine side effects like nausea, diarrhea, stomach pain, or muscle problems.
The good news: your care team knows how to handle this. Please don't stop or change either medicine on your own. Just check in with your pharmacist or doctor so they can adjust doses, plan the timing, or watch you more closely if you take both.
Mechanism: Vimseltinib inhibits P-glycoprotein (P-gp)-mediated efflux. Colchicine is a P-gp substrate, so co-administration reduces colchicine efflux and increases its systemic exposure (higher AUC/Cmax).
Direction: Increased colchicine effect and toxicity risk (GI toxicity, myelosuppression, neuromyopathy); risk is amplified in renal or hepatic impairment. Neither drug is a prodrug here.
- Severity: Major; evidence: probable; onset: unspecified.
- Management: Avoid concomitant use. If unavoidable, administer vimseltinib at least 4 hours before colchicine. Consider colchicine dose reduction and monitor for toxicity, especially with impaired clearance.
What happens
Increased risk of P-gp substrate exposure
Interaction Deep Dive
Refrain from giving vimseltinib together with P-gp substrates, since doing so can raise the exposure of the P-gp substrate. When such combined use is unavoidable, administer vimseltinib no less than 4 hours before the P-gp substrates1.
Why it happens (mechanism)
Inhibition of P-gp-mediated efflux transport by vimseltinib
How to manage this interaction
What your care team may do:
- When possible, avoid using these two together and consider an alternative.
- If both are needed, they may schedule vimseltinib to be taken at least 4 hours before colchicine.
- Your colchicine dose may need to be adjusted and individualized by your care team, and they may monitor you more closely for side effects.
What you should do: Keep taking both exactly as prescribed, and tell your pharmacist or doctor before making any change. Report symptoms like ongoing nausea, diarrhea, muscle pain or weakness, numbness, or feeling unusually tired or sick.
Management is individual — confirm any change with your pharmacist or prescriber.
Literature reports
1 report — tap to read
a) In a drug interaction study, the AUC (0 to inf) and Cmax of dabigatran (a P-gp substrate) are projected to rise 2- to 3-fold when taken together with vimseltinib 30 mg twice weekly. If dabigatran is given 4 hours or more after vimseltinib 30 mg twice weekly, its Cmax and AUC (0 to inf) are projected to rise up to 1.3-fold 1.
Common questions
Can I take Vimseltinib and Colchicine together?
Vimseltinib can raise colchicine levels and its side-effect risk, so avoid combining them if you can; if both are needed, take vimseltinib at least 4 hours before colchicine and ask your care team about dose adjustments and monitoring. Always confirm with your pharmacist or prescriber before making any change.
How serious is the Vimseltinib and Colchicine interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How is the Vimseltinib and Colchicine interaction managed?
What your care team may do: When possible, avoid using these two together and consider an alternative. If both are needed, they may schedule vimseltinib to be taken at least 4 hours before colchicine. Your colchicine dose may need to be adjusted and individualized by your care team, and they may monitor you more closely for side effects. What you should do: Keep taking both exactly as prescribed,… Management is individual — always follow your own care team's guidance.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
Questions for your pharmacist
- Does my dose of Vimseltinib or Colchicine need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: ROMVIMZA(TM) oral capsules, vimseltinib oral capsules. Deciphera Pharmaceuticals, LLC (per FDA), Waltham, MA, 2025. DailyMed
Keep reading about Colchicine
Keep reading about Vimseltinib
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