Ziprasidone

88 interactions 6 explained in plain English
Also sold as: Geodon
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ivabradine Octreotide Injection Hydroxychloroquine Ofloxacin Otic Linezolid Injection Amisulpride Injection
64 Contraindicated 22 Major 2 Moderate
All (88) Contraindicated (64) Major (22) Moderate (2)

Contraindicated

Ziprasidone Lefamulin Xenleta An increased risk of QT interval prolongation Details Ziprasidone Lenvatinib Lenvima An increased risk of QT interval prolongation Details Ziprasidone Levofloxacin Levaquin An increased risk of QT interval prolongation Details Ziprasidone Levofloxacin Injection Levaquin An increased risk of QT interval prolongation Details Ziprasidone Linezolid Injection Zyvox Increased risk for serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Ziprasidone Loperamide Diamode An increased risk of QT interval prolongation Details Ziprasidone Mefloquine Lariam® An increased risk of QT interval prolongation Details Ziprasidone Metoclopramide Injection Gimoti An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details Ziprasidone Metoclopramide Nasal Spray Gimoti An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details Ziprasidone Metronidazole Flagyl An increased risk of QT interval prolongation Details Ziprasidone Metronidazole Injection Flagyl An increased risk of QT interval prolongation Details Ziprasidone Metronidazole Topical MetroCream® An increased risk of QT interval prolongation Details Ziprasidone Metronidazole Vaginal MetroGel® Vaginal An increased risk of QT interval prolongation Details Ziprasidone Moxifloxacin Avelox An increased risk of QT interval prolongation Details Ziprasidone Moxifloxacin Injection Avelox An increased risk of QT interval prolongation Details Ziprasidone Moxifloxacin Ophthalmic Moxeza® An increased risk of QT interval prolongation Details Ziprasidone Nafarelin Nasal Spray Synarel An increased risk of QT interval prolongation Details Ziprasidone Octreotide Bynfezia An increased risk of QT interval prolongation Details Ziprasidone Octreotide Injection Bynfezia An increased risk of QT interval prolongation Details Ziprasidone Ofloxacin Floxin® An increased risk of QT interval prolongation Details Ziprasidone Ofloxacin Ophthalmic Ocuflox An increased risk of QT interval prolongation Details Ziprasidone Ofloxacin Otic Floxin® Otic An increased risk of QT interval prolongation Details Ziprasidone Olodaterol Oral Inhalation Striverdi An increased risk of QT interval prolongation Details Ziprasidone Oxaliplatin Injection Eloxatin® An increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.