Tryngolza Generic: When Will Generic Olezarsen Be Available?
This page is aggregated from FDA records, court filings and company announcements. Coded and designed by Dr. Brian Staiger, PharmD, BCPS
Updated October 9, 2026 How we build our data
Tryngolza Generic at a Glance
Four quick answers from FDA records and our estimate.
- When is the first generic expected? February 2038 About 11.5 years away Why then?
- Has the FDA approved a generic? Unknown No FDA Orange Book record under this name
- When does the brand’s protection end? Unknown Not in the FDA record we could read
- Can you buy a generic today? Not yet No company lists one for sale
Generic olezarsen sodium is expected to be available in February 2038, about 11.5 years away. None is for sale yet.
Why February 2038?
A patent that protects the brand runs out. After that, approved generics can be sold. We rate it probable: more likely than not, but it can still move.
Will the generic cost less?
Usually, but no company is recorded as having applied to make one yet, and a single company usually brings only a modest drop. See the price pattern
What should I do now?
Keep taking Tryngolza as prescribed. When a generic arrives, your pharmacy may switch you to it automatically, and it may look different. What a generic means for you
Our month is only an estimate based on available information, so we never name a day.
Tryngolza by the Numbers
- Reason
- Patent expiresA patent that protects the brand runs out. After that, approved generics can be sold.
- How sure
- Probable More likely than not, but it can still move.
- Price competition
- None filed yet No filers on record
- Brand sales
- $119M a yearBig seller
- Medicare Part D spent $29.6M in 2025, for 98 people CMS Part D Spending by Drug
- Medicaid prescriptions 178 in the last four reported quarters, $8.8M CMS Medicaid drug utilization, to Q1 2026
Tryngolza’s Road to a Generic
The first generic of Tryngolza is expected in February 2038.
Why that month: a patent that protects the brand runs out. After that, approved generics can be sold.
The bar shows Tryngolza on the market on its own until the month we expect the first generic (the green band), a month and never a day. Its approval date and patents are not in the FDA Orange Book under this name, so the bar fades in from the left. The expected month comes from court records and company announcements.
Who Is Lined Up to Make Generic Olezarsen Sodium
Three steps stand between a brand and a generic you can buy: a company applies to the FDA, the FDA approves it, and the company starts selling it.
Applied to the FDA
No company is recorded as having applied to the FDA to make a generic Tryngolza yet.
Approved by the FDA
We could not find Tryngolza’s own record in the FDA Orange Book under this name, so the approved generic makers are not shown.
For Sale in Pharmacies
Not yet. No company lists a generic olezarsen sodium for sale with the FDA.
Sources: how many companies have applied, from court records and company announcements; approved generics from the FDA Orange Book; what is for sale from the FDA NDC Directory. The FDA does not disclose an application before it approves it (21 CFR 314.430).
Tryngolza Price: What Pharmacies Pay and What Generics Usually Do
What a Generic Could Cost
How we estimate it. The national survey of what pharmacies pay (NADAC) has no recent price for Tryngolza, so we cannot show dollars. Here is the FDA’s finding of how far the price pharmacies pay usually falls as generic companies join: about 31% with one company, 44% with two, 73% with four and over 95% with six or more (the typical drop for every drug whose first generic came out from 2015 to 2017).
Median prices pharmacies paid for the generic (invoice prices), compared with the brand’s price before generic entry, from FDA’s 2019 analysis “Generic Competition and Drug Prices”. At the manufacturer’s price FDA found steeper drops (about 39%, 54%, 79% and over 95%), the figures quoted elsewhere on this tracker. A typical pattern, not a price quote for this medicine.
What Medicare and Medicaid Spend on Tryngolza
Big public spending is part of why generic makers line up for a medicine, and why its first generic matters beyond the pharmacy counter. Figures are before manufacturer rebates, which are confidential.
Medicare Part D Spending
What Medicare drug plans spent on Tryngolza, before manufacturer rebates.
- $11.2M
- January to March 2026, the latest CMS has posted
For 87 people, about $50,613 per prescription fill - $29.6M
- 2025, the whole year
For 98 people, about $50,470 per prescription fill
See the numbers
| Period | Spending | People | Per fill |
|---|---|---|---|
| January to March 2026 | $11,185,547 | 87 | $50,613.33 |
| 2025 | $29,625,744 | 98 | $50,469.75 |
Source: CMS Medicare Part D Spending by Drug, matched by the brand name Tryngolza only, so no generic is counted in it. What CMS says it is used for: Olezarsen is used along with a proper diet to help lower fats (triglycerides) in the blood. It is used by people who have a certain inherited condition (familial chylomicronemia syndrome) that causes high levels of triglycerides in the blood.
Medicaid Prescriptions by Quarter
178 prescriptions in the four quarters to Q1 2026, $8.8M paid.
See the numbers
| Quarter | Prescriptions | Medicaid paid |
|---|---|---|
| Q1 2026 | 70 | $3,472,664 |
| Q4 2025 | 77 | $3,833,120 |
| Q3 2025 | 31 | $1,537,446 |
| Q2 2025 | 0 | $0 |
| Q1 2025 | 0 | $0 |
Source: CMS Medicaid State Drug Utilization Data, over Tryngolza’s own package codes.
Tryngolza NDC Codes and Packages
Each Tryngolza package sold today has its own NDC, the product number printed on the box and on the pharmacy label. Open one to see that package’s details, what pharmacies pay for it and its patent timeline.
| NDC | Product | Package | Company |
|---|---|---|---|
| 71860-0102-01 | OLEZARSEN SODIUM 50 mg/.8mL injection, solution | syringe of .8 mL | Ionis Pharmaceuticals, Inc. |
| 71860-0101-01 | OLEZARSEN SODIUM 80 mg/.8mL injection, solution | syringe of .8 mL | Ionis Pharmaceuticals, Inc. |
Source: the FDA NDC Directory, current listings only. Some codes belong to companies that repackage Tryngolza: it is the same medicine in a different package.
What a Generic Tryngolza Means for You
Nothing Changes Until It Is in Pharmacies
Until a generic is actually for sale, keep filling Tryngolza as usual. When one arrives, there is nothing you need to sign up for.
Your Pharmacy May Switch You Automatically
Every state lets pharmacists fill a brand-name prescription with an FDA-approved generic rated as equivalent to it, and about 19 states require them to, unless your prescriber writes “dispense as written” or “brand medically necessary” on the prescription. Some states ask the pharmacist to tell you, or to get your OK first. A study of every state’s law has the details.
It Will Probably Look Different
US trademark law does not let a generic look exactly like the brand, so the color, shape or markings usually change. The active ingredient, strength and form are the same. An “authorized generic,” made by or for the brand’s own company, can look identical. The FDA explains.
Your Insurance May Change Too
Once a lower-cost version is available, many insurance plans charge more for the brand, or stop covering it. Your plan’s drug list (formulary) says how.
Until a generic is on US pharmacy shelves, be careful with websites that offer “generic Tryngolza”. The FDA warns that unlicensed online pharmacies sell counterfeit and unapproved medicines; its BeSafeRx page shows how to check a pharmacy.
Questions people ask about Tryngolza
Is there a generic for Tryngolza right now?
No. As of October 9, 2026 no generic olezarsen sodium is listed for sale in the FDA NDC Directory.
When will Tryngolza go generic?
February 2038 is the expected month, and that is probable but not certain. A patent that protects the brand runs out. After that, approved generics can be sold.
Will generic olezarsen sodium be the same as Tryngolza?
Yes in the ways that matter: the same active ingredient, strength and form, with proof that it reaches your blood the same way. Inactive ingredients can differ, which is why some people notice a different look or taste.
How much will the generic cost?
Nobody can say for sure before launch. No company is recorded as having applied to the FDA to make one yet, and a single company usually brings only a modest drop.
Changes to This Projection
- First generic expected February 2038 on this month’s schedule. A line is added here whenever a monthly update moves the month, the reason or how sure it is.
Every change to the expected month is logged here with the month we saw it.
Also Going Generic
- VyndaqelTafamidis MeglumineJuly to December 2028
- Spiriva RespimatTiotropium Bromide MonohydrateApril 2031
- Jornay PMMethylphenidate HydrochlorideMarch 2032
- Onzetra XsailSumatriptanOctober 2034
- EmpaveliPegcetacoplanDecember 2038
- AttrubyAcoramidis HydrochlorideMarch 2039
About Tryngolza
- Generic name olezarsen sodium
- How it is taken Injection under the skin
- Hard to copy Inhalers, injectables, patches and other hard-to-copy products. Fewer companies attempt them and dates slip more often.
- More drugs Brand-name drugs starting with T
- Have a question? A pharmacist answers, free. Ask about Tryngolza
Sources. The expected month: FDA Paragraph IV Patent Certifications list, federal court records, company announcements and securities filings (settlement dates, launch plans, sales). The record on this page: FDA Orange Book, FDA NDC Directory, CMS Medicare Part D Spending by Drug, Medicaid State Drug Utilization Data, FDA, Generic Competition and Drug Prices (2019). Updated October 9, 2026. Information, not medical advice.